LTBR (lymphotoxin beta receptor)

2003-06-01  

Identity

HGNC
LTBR
LOCATION
12p13.31
LOCUSID
4055
ALIAS
D12S370,LT-BETA-R,TNF-R-III,TNFCR,TNFR-RP,TNFR2-RP,TNFR3,TNFRSF3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4055
MIM: 600979
HGNC: 6718
Ensembl: ENSG00000111321

Variants:

dbSNP: 4055
ClinVar: 4055
TCGA: ENSG00000111321
COSMIC: LTBR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111321ENST00000228918P36941
ENSG00000111321ENST00000536876F5H6F8
ENSG00000111321ENST00000541102F5H2E7
ENSG00000111321ENST00000543190F5H1S5
ENSG00000111321ENST00000544454F5H627

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
HIF-1 signaling pathwayKEGGhsa04066
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayREACTOMER-HSA-5676594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381756862024Systematic analysis of the prognostic value and immunological function of LTBR in human cancer.1
385990712024Comprehensive analysis reveals that LTBR is a immune-related biomarker for glioma.1
381756862024Systematic analysis of the prognostic value and immunological function of LTBR in human cancer.1
385990712024Comprehensive analysis reveals that LTBR is a immune-related biomarker for glioma.1
359871372022A LIGHT-HVEM/LTβR axis contributes to the fibrosis of intrauterine adhesion.1
359871372022A LIGHT-HVEM/LTβR axis contributes to the fibrosis of intrauterine adhesion.1
335940672021LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells.7
336067812021LIGHT (TNFSF14) enhances osteogenesis of human bone marrow-derived mesenchymal stem cells.3
335940672021LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells.7
336067812021LIGHT (TNFSF14) enhances osteogenesis of human bone marrow-derived mesenchymal stem cells.3
319693872020Cutting Edge: The RNA-Binding Protein Ewing Sarcoma Is a Novel Modulator of Lymphotoxin β Receptor Signaling.1
331482722020Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor.5
331493052020Inhibition of LTβR signalling activates WNT-induced regeneration in lung.50
319693872020Cutting Edge: The RNA-Binding Protein Ewing Sarcoma Is a Novel Modulator of Lymphotoxin β Receptor Signaling.1
331482722020Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor.5

Citation

Dessen P

LTBR (lymphotoxin beta receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41216/cancer-prone-explorer/case-report-explorer/deep-insight-explorer/