MCF2L (MCF.2 cell line derived transforming sequence like)

2003-02-01 Affiliation

Identity

HGNC

MCF2L

LOCATION

13q34

LOCUSID

23263

ALIAS

ARHGEF14,DBS,OST

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23263
MIM: 609499
HGNC: 14576
Ensembl: ENSG00000126217

Variants:

dbSNP: 23263
ClinVar: 23263
TCGA: ENSG00000126217
COSMIC: MCF2L

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000126217	ENST00000261963	H3BLT1
ENSG00000126217	ENST00000375597	O15068
ENSG00000126217	ENST00000375604	O15068
ENSG00000126217	ENST00000375608	O15068
ENSG00000126217	ENST00000397017	H7BYP9
ENSG00000126217	ENST00000397021	A2A639
ENSG00000126217	ENST00000397024	A2A3G7
ENSG00000126217	ENST00000397030	O15068
ENSG00000126217	ENST00000397036	A2A3H1
ENSG00000126217	ENST00000409954	B7ZBR9
ENSG00000126217	ENST00000413354	H7C2S1
ENSG00000126217	ENST00000420013	H7C275
ENSG00000126217	ENST00000421756	O15068
ENSG00000126217	ENST00000423251	A2A640
ENSG00000126217	ENST00000433807	X6RE72
ENSG00000126217	ENST00000439475	H0Y7A3
ENSG00000126217	ENST00000441756	H0Y519
ENSG00000126217	ENST00000442625	F8WBK7
ENSG00000126217	ENST00000453297	H0Y4M6
ENSG00000126217	ENST00000473345	M0R393
ENSG00000126217	ENST00000486806	M0R1J7
ENSG00000126217	ENST00000535094	O15068

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signalling by NGF	REACTOME	R-HSA-166520
p75 NTR receptor-mediated signalling	REACTOME	R-HSA-193704
Cell death signalling via NRAGE, NRIF and NADE	REACTOME	R-HSA-204998
NRAGE signals death through JNK	REACTOME	R-HSA-193648
Signaling by Rho GTPases	REACTOME	R-HSA-194315
Rho GTPase cycle	REACTOME	R-HSA-194840
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (12/13) signalling events	REACTOME	R-HSA-416482

References

Pubmed ID	Year	Title	Citations
34592939	2021	LncRNA MCF2L-AS1 aggravates the malignant development of colorectal cancer via targeting miR-105-5p/RAB22A axis.	9
34592939	2021	LncRNA MCF2L-AS1 aggravates the malignant development of colorectal cancer via targeting miR-105-5p/RAB22A axis.	9
31732956	2020	miR-140-3p exhibits repressive functions on preosteoblast viability and differentiation by downregulating MCF2L in osteoporosis.	7
31732956	2020	miR-140-3p exhibits repressive functions on preosteoblast viability and differentiation by downregulating MCF2L in osteoporosis.	7
29039610	2017	Establishment of a human primary pancreatic cancer mouse model to examine and investigate gemcitabine resistance.	8
29039610	2017	Establishment of a human primary pancreatic cancer mouse model to examine and investigate gemcitabine resistance.	8
25898923	2016	A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis.	6
25898923	2016	A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis.	6
26584642	2015	Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874.	12
26584642	2015	Expression analysis of the osteoarthritis genetic susceptibility locus mapping to an intron of the MCF2L gene and marked by the polymorphism rs11842874.	12
22615457	2012	Genetic contribution to radiographic severity in osteoarthritis of the knee.	8
22615457	2012	Genetic contribution to radiographic severity in osteoarthritis of the knee.	8
21871595	2011	A variant in MCF2L is associated with osteoarthritis.	57
21871595	2011	A variant in MCF2L is associated with osteoarthritis.	57
19911011	2010	Mutation of ARHGAP9 in patients with coronary spastic angina.	0

Citation

Dessen P

MCF2L (MCF.2 cell line derived transforming sequence like)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41316/tumors-explorer/humanGenome