MGST1 (microsomal glutathione S-transferase 1)

2003-06-01  

Identity

HGNC
MGST1
LOCATION
12p12.3
LOCUSID
4257
ALIAS
GST12,MGST,MGST-I
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4257
MIM: 138330
HGNC: 7061
Ensembl: ENSG00000008394

Variants:

dbSNP: 4257
ClinVar: 4257
TCGA: ENSG00000008394
COSMIC: MGST1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008394ENST00000010404P10620
ENSG00000008394ENST00000010404A0A024RAX2
ENSG00000008394ENST00000396207P10620
ENSG00000008394ENST00000396207A0A024RAX2
ENSG00000008394ENST00000396209P10620
ENSG00000008394ENST00000396209A0A024RAX2
ENSG00000008394ENST00000396210P10620
ENSG00000008394ENST00000396210A0A024RAX2
ENSG00000008394ENST00000535309P10620
ENSG00000008394ENST00000536371F5H7F6
ENSG00000008394ENST00000538885F5GX73
ENSG00000008394ENST00000540056F5H613
ENSG00000008394ENST00000540126F5H6X2
ENSG00000008394ENST00000543076F5H760

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Aflatoxin activation and detoxificationREACTOMER-HSA-5423646
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Neutrophil degranulationREACTOMER-HSA-6798695
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371618542023Microsomal glutathione S-transferase 1 targets the autophagy signaling pathway to suppress ferroptosis in gastric carcinoma cells.3
373214502023A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression.1
371618542023Microsomal glutathione S-transferase 1 targets the autophagy signaling pathway to suppress ferroptosis in gastric carcinoma cells.3
373214502023A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression.1
335397322021MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells.64
341715412021MiR-379-5p targets microsomal glutathione transferase 1 (MGST1) to regulate human glioma in cell proliferation, migration and invasion and epithelial-mesenchymal transition (EMT).6
335397322021MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells.64
341715412021MiR-379-5p targets microsomal glutathione transferase 1 (MGST1) to regulate human glioma in cell proliferation, migration and invasion and epithelial-mesenchymal transition (EMT).6
317073412020Knockdown of microsomal glutathione S-transferase 1 inhibits lung adenocarcinoma cell proliferation and induces apoptosis.17
317073412020Knockdown of microsomal glutathione S-transferase 1 inhibits lung adenocarcinoma cell proliferation and induces apoptosis.17
296954042018Establishment and Characteristics of a Novel Mantle Cell Lymphoma-derived Cell Line and a Bendamustine-resistant Subline.6
297139842018Biomarkers of Barrett's Esophagus: From the Laboratory to Clinical Practice.8
296954042018Establishment and Characteristics of a Novel Mantle Cell Lymphoma-derived Cell Line and a Bendamustine-resistant Subline.6
297139842018Biomarkers of Barrett's Esophagus: From the Laboratory to Clinical Practice.8
274860972017Germline variation in inflammation-related pathways and risk of Barrett's oesophagus and oesophageal adenocarcinoma.27

Citation

Dessen P

MGST1 (microsomal glutathione S-transferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41361/tumors-explorer/css/lib/hgnc