MMP13 (matrix metallopeptidase 13)

2003-02-01  

Identity

HGNC
LOCATION
11q22.2
LOCUSID
ALIAS
CLG3,MANDP1,MDST,MMP-13
FUSION GENES

Other Information

Locus ID:

NCBI: 4322
MIM: 600108
HGNC: 7159
Ensembl: ENSG00000137745

Variants:

dbSNP: 4322
ClinVar: 4322
TCGA: ENSG00000137745
COSMIC: MMP13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137745ENST00000260302P45452
ENSG00000137745ENST00000340273G5E971
ENSG00000137745ENST00000615555Q7Z5M0

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Assembly of collagen fibrils and other multimeric structuresREACTOMER-HSA-2022090
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389
Collagen degradationREACTOMER-HSA-1442490
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
374897922024The Mediating Role of miR-451/ETV4/MMP13 Signaling Axis on Epithelialmesenchymal Transition in Promoting Non-small Cell Lung Cancer Progression.0
382518582024Breast cancer malignancy is governed by regulation of the macroH2A2/TM4SF1 axis, the AKT/NF-κB pathway, and elevated MMP13 expression.0
384714882024Human Host Defense Peptide LL-37 Suppresses TNFα-Mediated Matrix Metalloproteinases MMP9 and MMP13 in Human Bronchial Epithelial Cells.0
385279832024MMP1, MMP9, MMP11 and MMP13 in melanoma and its metastasis - key points in understanding the mechanisms and celerity of tumor dissemination.1
386196832024Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model by Reducing the Expression of Pdpn.1
387700932024TPX2 upregulates MMP13 to promote the progression of lipopolysaccharide-induced osteoarthritis.1
389369422024Association of Clinicopathological Factors With MMP13 (rs2252070) Gene Polymorphism in Swedish Patients With Colorectal Cancer.0
374897922024The Mediating Role of miR-451/ETV4/MMP13 Signaling Axis on Epithelialmesenchymal Transition in Promoting Non-small Cell Lung Cancer Progression.0
382518582024Breast cancer malignancy is governed by regulation of the macroH2A2/TM4SF1 axis, the AKT/NF-κB pathway, and elevated MMP13 expression.0
384714882024Human Host Defense Peptide LL-37 Suppresses TNFα-Mediated Matrix Metalloproteinases MMP9 and MMP13 in Human Bronchial Epithelial Cells.0
385279832024MMP1, MMP9, MMP11 and MMP13 in melanoma and its metastasis - key points in understanding the mechanisms and celerity of tumor dissemination.1
386196832024Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model by Reducing the Expression of Pdpn.1
387700932024TPX2 upregulates MMP13 to promote the progression of lipopolysaccharide-induced osteoarthritis.1
389369422024Association of Clinicopathological Factors With MMP13 (rs2252070) Gene Polymorphism in Swedish Patients With Colorectal Cancer.0
364090422023Increased expression of angiopoietin-like protein 4 regulates matrix metalloproteinase-13 expression in Porphyromonas gingivalis lipopolysaccharides-stimulated gingival fibroblasts and ligature-induced experimental periodontitis.1

Citation

Dessen P

MMP13 (matrix metallopeptidase 13)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41390/js/lib/css/gene-fusions/?id=41390