MMP17 (matrix metallopeptidase 17)

2003-06-01  

Identity

HGNC
MMP17
LOCATION
12q24.33
LOCUSID
4326
ALIAS
MMP-17,MT4-MMP,MT4MMP,MTMMP4

Other Information

Locus ID:

NCBI: 4326
MIM: 602285
HGNC: 7163
Ensembl: ENSG00000198598

Variants:

dbSNP: 4326
ClinVar: 4326
TCGA: ENSG00000198598
COSMIC: MMP17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198598ENST00000360564Q9ULZ9
ENSG00000198598ENST00000534865F5H881
ENSG00000198598ENST00000535004F5H209
ENSG00000198598ENST00000535291Q9ULZ9
ENSG00000198598ENST00000537848F5H846
ENSG00000198598ENST00000542648F5H249
ENSG00000198598ENST00000545671F5GZA7
ENSG00000198598ENST00000545790F5GWR3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389

References

Pubmed IDYearTitleCitations
383104352023Elevated Plasma Levels of MT4-MMP and MT6-MMP; A New Observation in Patients with Thyroid Nodules.0
383104352023Elevated Plasma Levels of MT4-MMP and MT6-MMP; A New Observation in Patients with Thyroid Nodules.0
360426262022Increased expression of MMP17 predicts poor clinical outcomes in epithelial ovarian cancer patients.5
360426262022Increased expression of MMP17 predicts poor clinical outcomes in epithelial ovarian cancer patients.5
318135462020MT4-MMP promotes invadopodia formation and cell motility in FaDu head and neck cancer cells.9
318135462020MT4-MMP promotes invadopodia formation and cell motility in FaDu head and neck cancer cells.9
295004072018MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis.19
307921642018MT4-MMP Modulates the Expression of miRNAs in Breast Cancer Cells.0
295004072018MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis.19
307921642018MT4-MMP Modulates the Expression of miRNAs in Breast Cancer Cells.0
281960642017MT4-MMP and EGFR expression levels are key biomarkers for breast cancer patient response to chemotherapy and erlotinib.9
285318872017Expression and Characterization of Membrane-Type 4 Matrix Metalloproteinase (MT4-MMP) and its Different Forms in Melanoma.3
281960642017MT4-MMP and EGFR expression levels are key biomarkers for breast cancer patient response to chemotherapy and erlotinib.9
285318872017Expression and Characterization of Membrane-Type 4 Matrix Metalloproteinase (MT4-MMP) and its Different Forms in Melanoma.3
266630282016Dynamics of internalization and recycling of the prometastatic membrane type 4 matrix metalloproteinase (MT4-MMP) in breast cancer cells.10

Citation

Dessen P

MMP17 (matrix metallopeptidase 17)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41394/deep-insight-explorer/gene-fusions-explorer/