MRS2 (magnesium transporter MRS2)

2003-05-01  

Identity

HGNC
MRS2
LOCATION
6p22.3
LOCUSID
57380
ALIAS
HPT,MRS2L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57380
HGNC: 13785
Ensembl: ENSG00000124532

Variants:

dbSNP: 57380
ClinVar: 57380
TCGA: ENSG00000124532
COSMIC: MRS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124532ENST00000274747A0A0A0MQX2
ENSG00000124532ENST00000378353Q9HD23
ENSG00000124532ENST00000378386Q9HD23
ENSG00000124532ENST00000443868Q9HD23
ENSG00000124532ENST00000446191H7BZ29

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Miscellaneous transport and binding eventsREACTOMER-HSA-5223345

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
385993042024Mrs2-mediated mitochondrial magnesium uptake is essential for the regulation of MCU-mediated mitochondrial Ca(2+) uptake and viability.1
385993042024Mrs2-mediated mitochondrial magnesium uptake is essential for the regulation of MCU-mediated mitochondrial Ca(2+) uptake and viability.1
367545682023The human MRS2 magnesium-binding domain is a regulatory feedback switch for channel activity.6
375436492023Molecular basis of Mg(2+) permeation through the human mitochondrial Mrs2 channel.8
379385622023Cryo-EM structures of human magnesium channel MRS2 reveal gating and regulatory mechanisms.3
367545682023The human MRS2 magnesium-binding domain is a regulatory feedback switch for channel activity.6
375436492023Molecular basis of Mg(2+) permeation through the human mitochondrial Mrs2 channel.8
379385622023Cryo-EM structures of human magnesium channel MRS2 reveal gating and regulatory mechanisms.3
274580512016Mitochondrial Mg(2+) homeostasis decides cellular energy metabolism and vulnerability to stress.66
274580512016Mitochondrial Mg(2+) homeostasis decides cellular energy metabolism and vulnerability to stress.66
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
183846652009Conditional knockdown of hMRS2 results in loss of mitochondrial Mg(2+) uptake and cell death.30
192420982009Human mitochondrial Mrs2 protein promotes multidrug resistance in gastric cancer cells by regulating p27, cyclin D1 expression and cytochrome C release.21
192705012009Multidrug resistance phenotypes and MRS2 mitochondrial magnesium channel: two players from one stemness?7

Citation

Dessen P

MRS2 (magnesium transporter MRS2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41430/cancer-prone-explorer/haematological-explorer/