NFKBIB (NFKB inhibitor beta)

2003-08-01 Affiliation

Identity

HGNC

NFKBIB

LOCATION

19q13.2

LOCUSID

4793

ALIAS

IKBB,TRIP9

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4793
MIM: 604495
HGNC: 7798
Ensembl: ENSG00000104825

Variants:

dbSNP: 4793
ClinVar: 4793
TCGA: ENSG00000104825
COSMIC: NFKBIB

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000104825	ENST00000313582	Q15653
ENSG00000104825	ENST00000392079	G5E9C2
ENSG00000104825	ENST00000509705	H0YFH0
ENSG00000104825	ENST00000572515	Q15653
ENSG00000104825	ENST00000575359	I3L1A4
ENSG00000104825	ENST00000576510	I3L4X3

Expression (GTEx)

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
T cell receptor signaling pathway	KEGG	ko04660
B cell receptor signaling pathway	KEGG	ko04662
Adipocytokine signaling pathway	KEGG	ko04920
T cell receptor signaling pathway	KEGG	hsa04660
B cell receptor signaling pathway	KEGG	hsa04662
Adipocytokine signaling pathway	KEGG	hsa04920
Shigellosis	KEGG	hsa05131
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
Neurotrophin signaling pathway	KEGG	ko04722
Neurotrophin signaling pathway	KEGG	hsa04722
RIG-I-like receptor signaling pathway	KEGG	ko04622
RIG-I-like receptor signaling pathway	KEGG	hsa04622
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Cytosolic DNA-sensing pathway	KEGG	ko04623
Cytosolic DNA-sensing pathway	KEGG	hsa04623
Leishmaniasis	KEGG	ko05140
Leishmaniasis	KEGG	hsa05140
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Measles	KEGG	ko05162
Measles	KEGG	hsa05162
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Disease	REACTOME	R-HSA-1643685
Diseases of Immune System	REACTOME	R-HSA-5260271
Diseases associated with the TLR signaling cascade	REACTOME	R-HSA-5602358
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	REACTOME	R-HSA-5603027
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
Activation of NF-kappaB in B cells	REACTOME	R-HSA-1169091
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 10 (TLR10) Cascade	REACTOME	R-HSA-168142
MyD88 cascade initiated on plasma membrane	REACTOME	R-HSA-975871
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	REACTOME	R-HSA-445989
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
Toll Like Receptor 5 (TLR5) Cascade	REACTOME	R-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) Cascade	REACTOME	R-HSA-168181
MyD88 dependent cascade initiated on endosome	REACTOME	R-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	REACTOME	R-HSA-975138
Toll Like Receptor 9 (TLR9) Cascade	REACTOME	R-HSA-168138
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
MyD88:Mal cascade initiated on plasma membrane	REACTOME	R-HSA-166058
Toll Like Receptor 2 (TLR2) Cascade	REACTOME	R-HSA-181438
Toll Like Receptor TLR1:TLR2 Cascade	REACTOME	R-HSA-168179
Toll Like Receptor TLR6:TLR2 Cascade	REACTOME	R-HSA-168188
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	REACTOME	R-HSA-168928
TRAF6 mediated NF-kB activation	REACTOME	R-HSA-933542
Cytosolic sensors of pathogen-associated DNA	REACTOME	R-HSA-1834949
ZBP1(DAI) mediated induction of type I IFNs	REACTOME	R-HSA-1606322
RIP-mediated NFkB activation via ZBP1	REACTOME	R-HSA-1810476
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA131301952	gefitinib	Chemical	ClinicalAnnotation	associated		PD	31664190
PA164925725	Toxic liver disease	Disease	ClinicalAnnotation	associated		PD	31664190

References

Pubmed ID	Year	Title	Citations
32017069	2020	The NF-κB regulator IκBβ exhibits different molecular interactivity and phosphorylation status from IκBα in an IKK2-catalysed reaction.	5
32017069	2020	The NF-κB regulator IκBβ exhibits different molecular interactivity and phosphorylation status from IκBα in an IKK2-catalysed reaction.	5
28314790	2017	Selinexor (KPT-330) Induces Tumor Suppression through Nuclear Sequestration of IκB and Downregulation of Survivin.	23
28448456	2017	Upregulation of miRNA-4776 in Influenza Virus Infected Bronchial Epithelial Cells Is Associated with Downregulation of NFKBIB and Increased Viral Survival.	18
28314790	2017	Selinexor (KPT-330) Induces Tumor Suppression through Nuclear Sequestration of IκB and Downregulation of Survivin.	23
28448456	2017	Upregulation of miRNA-4776 in Influenza Virus Infected Bronchial Epithelial Cells Is Associated with Downregulation of NFKBIB and Increased Viral Survival.	18
26227166	2016	IKBB tumor suppressive role in nasopharyngeal carcinoma via NF-κB-mediated signalling.	8
26227166	2016	IKBB tumor suppressive role in nasopharyngeal carcinoma via NF-κB-mediated signalling.	8
25326706	2014	Genetic polymorphisms and risk of recurrent wheezing in pediatric age.	11
25326706	2014	Genetic polymorphisms and risk of recurrent wheezing in pediatric age.	11
20056178	2010	Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.	6
20140262	2010	Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.	17
20448286	2010	Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways.	26
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	15
20716621	2010	Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.	12

Citation

Dessen P

NFKBIB (NFKB inhibitor beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41531/gene-fusions-explorer/teaching-explorer/