NOXA1 (NADPH oxidase activator 1)

2003-06-01 Affiliation

Identity

HGNC

NOXA1

LOCATION

9q34.3

LOCUSID

10811

ALIAS

NY-CO-31,SDCCAG31,p51NOX

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10811
MIM: 611255
HGNC: 10668
Ensembl: ENSG00000188747

Variants:

dbSNP: 10811
ClinVar: 10811
TCGA: ENSG00000188747
COSMIC: NOXA1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000188747	ENST00000341349	Q86UR1
ENSG00000188747	ENST00000392815	Q86UR1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases Activate NADPH Oxidases	REACTOME	R-HSA-5668599

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
32015503	2020	MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment.	20
32094511	2020	MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex.	20
32847975	2020	The Novel Histone Deacetylase Inhibitor, OBP-801, Induces Apoptosis in Rhabdoid Tumors by Releasing the Silencing of NOXA.	2
32015503	2020	MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment.	20
32094511	2020	MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex.	20
32847975	2020	The Novel Histone Deacetylase Inhibitor, OBP-801, Induces Apoptosis in Rhabdoid Tumors by Releasing the Silencing of NOXA.	2
31285435	2019	Noxa mitochondrial targeting domain induces necrosis via VDAC2 and mitochondrial catastrophe.	9
31727958	2019	Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies.	28
31285435	2019	Noxa mitochondrial targeting domain induces necrosis via VDAC2 and mitochondrial catastrophe.	9
31727958	2019	Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies.	28
29374147	2018	Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells.	15
29374147	2018	Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells.	15
28625920	2017	C-terminal tail of NADPH oxidase organizer 1 (Noxo1) mediates interaction with NADPH oxidase activator (Noxa1) in the NOX1 complex.	3
28625920	2017	C-terminal tail of NADPH oxidase organizer 1 (Noxo1) mediates interaction with NADPH oxidase activator (Noxa1) in the NOX1 complex.	3
23957209	2013	Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1.	9

Citation

Dessen P

NOXA1 (NADPH oxidase activator 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41563/gene-explorer/humanGenome