NTN1 (netrin 1)

2003-06-01  

Identity

HGNC
NTN1
LOCATION
17p13.1
LOCUSID
9423
ALIAS
MRMV4,NTN1L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9423
MIM: 601614
HGNC: 8029
Ensembl: ENSG00000065320

Variants:

dbSNP: 9423
ClinVar: 9423
TCGA: ENSG00000065320
COSMIC: NTN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000065320ENST00000173229O95631
ENSG00000065320ENST00000436734H7BZF4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Cell-Cell communicationREACTOMER-HSA-1500931
DSCAM interactionsREACTOMER-HSA-376172
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
DCC mediated attractive signalingREACTOMER-HSA-418885
Netrin mediated repulsion signalsREACTOMER-HSA-418886
Role of second messengers in netrin-1 signalingREACTOMER-HSA-418890

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
191226552009Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia.157
222315192012The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques.109
162039812005Netrin-1 inhibits leukocyte migration in vitro and in vivo.103
146020712003Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration.85
155731192004Netrin-1 and its receptors in tumorigenesis.83
183539832008Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer.83
245841182014Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.81
200753882010Netrin-1 dampens pulmonary inflammation during acute lung injury.54
192114412009Interference with netrin-1 and tumor cell death in non-small cell lung cancer.48
200800972010Netrin-1 mediates early events in pancreatic adenocarcinoma progression, acting on tumor and endothelial cells.46

Citation

Dessen P

NTN1 (netrin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41588/ntn1-(netrin-1)