PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase)

2003-05-01  

Identity

HGNC
PCMT1
LOCATION
6q25.1
LOCUSID
5110
ALIAS
PIMT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5110
MIM: 176851
HGNC: 8728
Ensembl: ENSG00000120265

Variants:

dbSNP: 5110
ClinVar: 5110
TCGA: ENSG00000120265
COSMIC: PCMT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120265ENST00000367378P22061
ENSG00000120265ENST00000367378A0A384MDK7
ENSG00000120265ENST00000367380A0A3F2YNX8
ENSG00000120265ENST00000367384P22061
ENSG00000120265ENST00000460828F8WDT3
ENSG00000120265ENST00000464889P22061
ENSG00000120265ENST00000464889A0A384MDK7
ENSG00000120265ENST00000484601F8WAV5
ENSG00000120265ENST00000486585H7C4X2
ENSG00000120265ENST00000494411F8WAX2
ENSG00000120265ENST00000495487C9J0F2
ENSG00000120265ENST00000544496F6S8N6
ENSG00000120265ENST00000649295A0A0A0MRJ6

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein repairREACTOMER-HSA-5676934

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366392652023In vitro Anti-malignant Property of PCMT1 Silencing and Identification of the SNHG16/miR-195/PCMT1 Regulatory Axis in Breast Cancer Cells.3
371571182023The role of PIMT in Alzheimer's disease pathogenesis: A novel hypothesis.3
375358522023The Role of Protein-L-isoaspartyl Methyltransferase (PIMT) in the Suppression of Toxicity of the Oligomeric Form of Aβ42, in Addition to the Inhibition of Its Fibrillization.0
375966542023PCMT1 is a potential target related to tumor progression and immune infiltration in liver cancer.0
378991702023PCMT1 regulates the migration, invasion, and apoptosis of prostate cancer through modulating the PI3K/AKT/GSK-3β pathway.1
379537892023PCMT1 knockdown attenuates malignant properties by globally regulating transcriptome profiles in triple-negative breast cancer cells.1
381620702023[Prognostic Value of PCMT1 Expression in Gastric Cancer and Its Regulatory Effect on Spindle Assembly Checkpoints].0
366392652023In vitro Anti-malignant Property of PCMT1 Silencing and Identification of the SNHG16/miR-195/PCMT1 Regulatory Axis in Breast Cancer Cells.3
371571182023The role of PIMT in Alzheimer's disease pathogenesis: A novel hypothesis.3
375358522023The Role of Protein-L-isoaspartyl Methyltransferase (PIMT) in the Suppression of Toxicity of the Oligomeric Form of Aβ42, in Addition to the Inhibition of Its Fibrillization.0
375966542023PCMT1 is a potential target related to tumor progression and immune infiltration in liver cancer.0
378991702023PCMT1 regulates the migration, invasion, and apoptosis of prostate cancer through modulating the PI3K/AKT/GSK-3β pathway.1
379537892023PCMT1 knockdown attenuates malignant properties by globally regulating transcriptome profiles in triple-negative breast cancer cells.1
381620702023[Prognostic Value of PCMT1 Expression in Gastric Cancer and Its Regulatory Effect on Spindle Assembly Checkpoints].0
350331722022Genome-wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis.20

Citation

Dessen P

PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41669/css/cancer-prone-explorer/gene-fusions/?id=41669