PIM2 (Pim-2 proto-oncogene, serine/threonine kinase)

2003-02-01  

Identity

HGNC
PIM2
LOCATION
Xp11.23
LOCUSID
11040
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11040
MIM: 300295
HGNC: 8987
Ensembl: ENSG00000102096

Variants:

dbSNP: 11040
ClinVar: 11040
TCGA: ENSG00000102096
COSMIC: PIM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102096ENST00000376509Q9P1W9
ENSG00000102096ENST00000376509A0A024QYW7
ENSG00000102096ENST00000442430C9J8V9

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Acute myeloid leukemiaKEGGko05221
Acute myeloid leukemiaKEGGhsa05221

References

Pubmed IDYearTitleCitations
370599672023PIM2 Promotes the Development of Ovarian Endometriosis by Enhancing Glycolysis and Fibrosis.1
370599672023PIM2 Promotes the Development of Ovarian Endometriosis by Enhancing Glycolysis and Fibrosis.1
351083592022PIM2 kinase has a pivotal role in plasmablast generation and plasma cell survival, opening up novel treatment options in myeloma.4
361095232022Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis.10
351083592022PIM2 kinase has a pivotal role in plasmablast generation and plasma cell survival, opening up novel treatment options in myeloma.4
361095232022Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis.10
339319812021Positive regulation of PFKFB3 by PIM2 promotes glycolysis and paclitaxel resistance in breast cancer.20
345110422021Long non-coding RNA SOX21-AS1 modulates lung cancer progress upon microRNA miR-24-3p/PIM2 axis.16
339319812021Positive regulation of PFKFB3 by PIM2 promotes glycolysis and paclitaxel resistance in breast cancer.20
345110422021Long non-coding RNA SOX21-AS1 modulates lung cancer progress upon microRNA miR-24-3p/PIM2 axis.16
318943002020Inhibition of PIM2 in liver cancer decreases tumor cell proliferation in vitro and in vivo primarily through the modulation of cell cycle progression.12
326417492020PIM2 promotes hepatocellular carcinoma tumorigenesis and progression through activating NF-κB signaling pathway.12
327542662020Fructose-1, 6-bisphosphatase 1 interacts with NF-κB p65 to regulate breast tumorigenesis via PIM2 induced phosphorylation.10
318943002020Inhibition of PIM2 in liver cancer decreases tumor cell proliferation in vitro and in vivo primarily through the modulation of cell cycle progression.12
326417492020PIM2 promotes hepatocellular carcinoma tumorigenesis and progression through activating NF-κB signaling pathway.12

Citation

Dessen P

PIM2 (Pim-2 proto-oncogene, serine/threonine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41718/js/lib/case-report-explorer/