PLOD1 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 1)

2003-05-01  

Identity

HGNC
PLOD1
LOCATION
1p36.22
LOCUSID
5351
ALIAS
EDS6,EDSKCL1,LH,LH1,LLH,PLOD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5351
MIM: 153454
HGNC: 9081
Ensembl: ENSG00000083444

Variants:

dbSNP: 5351
ClinVar: 5351
TCGA: ENSG00000083444
COSMIC: PLOD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000083444ENST00000196061Q02809
ENSG00000083444ENST00000196061A0A024R4H0
ENSG00000083444ENST00000429000Q5JXB7
ENSG00000083444ENST00000449038Q5JXB8

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Lysine degradationKEGGhsa00310
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Collagen biosynthesis and modifying enzymesREACTOMER-HSA-1650814

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366956932023miR-449a ameliorates acute rejection after liver transplantation via targeting procollagen-lysine1,2-oxoglutarate5-dioxygenase 1 in macrophages.1
366956932023miR-449a ameliorates acute rejection after liver transplantation via targeting procollagen-lysine1,2-oxoglutarate5-dioxygenase 1 in macrophages.1
344003652022New mechanistic insights to PLOD1-mediated human vascular disease.10
348455712022PLOD1 acts as a tumor promoter in glioma via activation of the HSF1 signaling pathway.4
351499722022P3H4 and PLOD1 expression associates with poor prognosis in bladder cancer.3
344003652022New mechanistic insights to PLOD1-mediated human vascular disease.10
348455712022PLOD1 acts as a tumor promoter in glioma via activation of the HSF1 signaling pathway.4
351499722022P3H4 and PLOD1 expression associates with poor prognosis in bladder cancer.3
334203702021Hypoxia-induced PLOD1 overexpression contributes to the malignant phenotype of glioblastoma via NF-κB signaling.23
334835982021PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43.8
335793422021A floppy infant without lingual frenulum and kyphoscoliosis: Ehlers Danlos syndrome case report.2
343040932021Characterization of a cancer-associated Epstein-Barr virus EBNA1 variant reveals a novel interaction with PLOD1 and PLOD3.4
344557622021PLOD1 promotes cell growth and aerobic glycolysis by regulating the SOX9/PI3K/Akt/mTOR signaling pathway in gastric cancer.8
334203702021Hypoxia-induced PLOD1 overexpression contributes to the malignant phenotype of glioblastoma via NF-κB signaling.23
334835982021PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43.8

Citation

Dessen P

PLOD1 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41749/css/tumors-explorer/tumors-explorer/