PPP1R15A (protein phosphatase 1 regulatory subunit 15A)

2003-08-01  

Identity

HGNC
PPP1R15A
LOCATION
19q13.33
LOCUSID
23645
ALIAS
GADD34
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23645
MIM: 611048
HGNC: 14375
Ensembl: ENSG00000087074

Variants:

dbSNP: 23645
ClinVar: 23645
TCGA: ENSG00000087074
COSMIC: PPP1R15A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087074ENST00000200453O75807
ENSG00000087074ENST00000600406M0QXL1

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling activates SMADsREACTOMER-HSA-2173789
Downregulation of TGF-beta receptor signalingREACTOMER-HSA-2173788

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383657642024Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers.0
386028762024Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress.0
383657642024Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers.0
386028762024Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress.0
381391502023The PPP1R15 Family of eIF2-alpha Phosphatase Targeting Subunits (GADD34 and CReP).3
381391502023The PPP1R15 Family of eIF2-alpha Phosphatase Targeting Subunits (GADD34 and CReP).3
349853362022Enterovirus 71 Activates GADD34 via Precursor 3CD to Promote IRES-Mediated Viral Translation.3
349853362022Enterovirus 71 Activates GADD34 via Precursor 3CD to Promote IRES-Mediated Viral Translation.3
346257482021Higher-order phosphatase-substrate contacts terminate the integrated stress response.10
347327482021Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF.7
348477772021Substrate recognition determinants of human eIF2α phosphatases.3
346257482021Higher-order phosphatase-substrate contacts terminate the integrated stress response.10
347327482021Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF.7
348477772021Substrate recognition determinants of human eIF2α phosphatases.3
329781592020GADD34 is a modulator of autophagy during starvation.29

Citation

Dessen P

PPP1R15A (protein phosphatase 1 regulatory subunit 15A)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41808/img/meetings/