PPP4C (protein phosphatase 4 catalytic subunit)

2003-11-01  

Identity

HGNC
PPP4C
LOCATION
16p11.2
LOCUSID
5531
ALIAS
PP-X,PP4,PP4C,PPH3,PPP4,PPX

Other Information

Locus ID:

NCBI: 5531
MIM: 602035
HGNC: 9319
Ensembl: ENSG00000149923

Variants:

dbSNP: 5531
ClinVar: 5531
TCGA: ENSG00000149923
COSMIC: PPP4C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149923ENST00000279387P60510
ENSG00000149923ENST00000279387A0A024R625
ENSG00000149923ENST00000561610P60510
ENSG00000149923ENST00000561610A0A024R625
ENSG00000149923ENST00000562222H3BV22
ENSG00000149923ENST00000562664H3BTA2
ENSG00000149923ENST00000563597H3BVE3
ENSG00000149923ENST00000563732H3BPN5
ENSG00000149923ENST00000566749I3L4X0
ENSG00000149923ENST00000627746H3BPN5

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384241482024AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner.0
390266742024Comprehensive analysis of PPP4C's impact on prognosis, immune microenvironment, and immunotherapy response in lung adenocarcinoma using single-cell sequencing and multi-omics.0
384241482024AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner.0
390266742024Comprehensive analysis of PPP4C's impact on prognosis, immune microenvironment, and immunotherapy response in lung adenocarcinoma using single-cell sequencing and multi-omics.0
364588272023Loss of PP4 contributes to diesel exhaust particles-induced epithelial barrier integrity disruption and alarmins release.2
373098982023SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex.3
377594422023Protein Phosphatase 4 Is Required for Centrobin Function in DNA Damage Repair.1
379066282023DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11.1
364588272023Loss of PP4 contributes to diesel exhaust particles-induced epithelial barrier integrity disruption and alarmins release.2
373098982023SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex.3
377594422023Protein Phosphatase 4 Is Required for Centrobin Function in DNA Damage Repair.1
379066282023DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11.1
349646992022Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancer.8
349646992022Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancer.8
321392572020PP4C facilitates lung cancer proliferation and inhibits apoptosis via activating MAPK/ERK pathway.10

Citation

Dessen P

PPP4C (protein phosphatase 4 catalytic subunit)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41824/meetings/teaching-explorer/