PTPRC (protein tyrosine phosphatase receptor type C)

2003-11-01  

Identity

HGNC
PTPRC
LOCATION
1q31.3
LOCUSID
5788
ALIAS
B220,CD45,CD45R,GP180,L-CA,LCA,LY5,T200
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5788
MIM: 151460
HGNC: 9666
Ensembl: ENSG00000081237

Variants:

dbSNP: 5788
ClinVar: 5788
TCGA: ENSG00000081237
COSMIC: PTPRC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000081237ENST00000348564P08575
ENSG00000081237ENST00000367364M9MMK8
ENSG00000081237ENST00000367367M3ZCP1
ENSG00000081237ENST00000367379M9MMK9
ENSG00000081237ENST00000413409M9MML4
ENSG00000081237ENST00000418674M9MML3
ENSG00000081237ENST00000442510P08575
ENSG00000081237ENST00000529828A0A075B788
ENSG00000081237ENST00000530727E9PKH0
ENSG00000081237ENST00000643513A0A2R8YE81
ENSG00000081237ENST00000645247A0A2R8Y5B1

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
T cell receptor signaling pathwayKEGGko04660
Primary immunodeficiencyKEGGko05340
Cell adhesion molecules (CAMs)KEGGhsa04514
T cell receptor signaling pathwayKEGGhsa04660
Primary immunodeficiencyKEGGhsa05340
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Phosphorylation of CD3 and TCR zeta chainsREACTOMER-HSA-202427
Innate Immune SystemREACTOMER-HSA-168249
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Other semaphorin interactionsREACTOMER-HSA-416700
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10004adalimumabChemicalClinicalAnnotationassociatedPD20309874, 23007924
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD20309874, 23007924
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD20309874, 23007924
PA449515etanerceptChemicalClinicalAnnotationassociatedPD20309874, 23007924
PA452639infliximabChemicalClinicalAnnotationassociatedPD20309874, 23007924

References

Pubmed IDYearTitleCitations
381710362024Frequent expression of CD45RO memory T cell marker as well as low to high expression of PD-1 and PD-L1 inhibitory molecules in seminoma and dysgerminoma.0
384114342024[CD45 pre-exclusion from the tips of microvilli : role in their activation].0
385755832024Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis.0
388806512024Lymphocyte Phosphatase-Associated Phosphoprotein (LPAP) as a CD45 Protein Stability Regulator.0
381710362024Frequent expression of CD45RO memory T cell marker as well as low to high expression of PD-1 and PD-L1 inhibitory molecules in seminoma and dysgerminoma.0
384114342024[CD45 pre-exclusion from the tips of microvilli : role in their activation].0
385755832024Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis.0
388806512024Lymphocyte Phosphatase-Associated Phosphoprotein (LPAP) as a CD45 Protein Stability Regulator.0
366371252023Upregulation of PTPRC and Interferon Response Pathways in HIV-1 Seroconverters Prior to Infection.0
369242332023CD45 Is Sufficient to Initiate Endothelial-to-Mesenchymal Transition in Human Endothelial Cells-Brief Report.1
375085382023CD45RA and CD45RO Are Regulated in a Cell-Type Specific Manner in Inflammation and Sepsis.0
375510932023Eosinophilic allergic rhinitis is strongly associated with the CD45RB(lo) subset of CD161(+) Th2 cells that secretes IL-2, IL-3, IL-4, IL-5, IL-9, and IL-13.3
376766222023CD45(-) erythroid progenitor cells promote lymph node metastasis in gastric cancer by inducing a hybrid epithelial/mesenchymal state in lymphatic endothelial cells.0
379739642023Plasma-derived extracellular vesicle surface markers CD45, CD326 and CD56 correlate with the stage of osteoarthritis: a primary study of a novel and promising diagnostic tool of the disease.0
379964892023PTPRC functions as a prognosis biomarker in the tumor microenvironment of cutaneous melanoma.0

Citation

Dessen P

PTPRC (protein tyrosine phosphatase receptor type C)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41925/gene-fusions/case-report-explorer/deep-insight-explorer/