PTPRK (protein tyrosine phosphatase receptor type K)

2003-11-01  

Identity

HGNC
PTPRK
LOCATION
6q22.33
LOCUSID
5796
ALIAS
R-PTP-kappa
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5796
MIM: 602545
HGNC: 9674
Ensembl: ENSG00000152894

Variants:

dbSNP: 5796
ClinVar: 5796
TCGA: ENSG00000152894
COSMIC: PTPRK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152894ENST00000368207E9PGC5
ENSG00000152894ENST00000368210Q5TG12
ENSG00000152894ENST00000368213Q15262
ENSG00000152894ENST00000368215Q15262
ENSG00000152894ENST00000368226Q15262
ENSG00000152894ENST00000392449Q6P493
ENSG00000152894ENST00000415046H0Y6P5
ENSG00000152894ENST00000415055H0Y6V4
ENSG00000152894ENST00000490332H0YDP9
ENSG00000152894ENST00000525459E9PRW2
ENSG00000152894ENST00000531050H0YD44
ENSG00000152894ENST00000532331Q15262
ENSG00000152894ENST00000532751E9PMV4

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR downregulationREACTOMER-HSA-182971

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
364365632023Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains.2
364365632023Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains.2
361299152022Investigation of cell signalings and therapeutic targets in PTPRK-RSPO3 fusion-positive colorectal cancer.0
366119092022PTPRK, an EGFR Phosphatase, Is Decreased in CeD Biopsies and Intestinal Organoids.2
361299152022Investigation of cell signalings and therapeutic targets in PTPRK-RSPO3 fusion-positive colorectal cancer.0
366119092022PTPRK, an EGFR Phosphatase, Is Decreased in CeD Biopsies and Intestinal Organoids.2
345905842021A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling.3
345905842021A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling.3
319348542020The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer.19
330686712020Simulation of multiple microenvironments shows a pivot role of RPTPs on the control of Epithelial-to-Mesenchymal Transition.1
319348542020The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer.19
330686712020Simulation of multiple microenvironments shows a pivot role of RPTPs on the control of Epithelial-to-Mesenchymal Transition.1
308381702019Downregulation of PTPRK Promotes Cell Proliferation and Metastasis of NSCLC by Enhancing STAT3 Activation.3
309247702019The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion.20
309473812019PTPRK suppresses progression and chemo-resistance of colon cancer cells via direct inhibition of pro-oncogenic CD133.6

Citation

Dessen P

PTPRK (protein tyrosine phosphatase receptor type K)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41933/teaching-explorer/haematological-explorer/