RAB4A (RAB4A, member RAS oncogene family)

2003-11-01  

Identity

HGNC
RAB4A
LOCATION
1q42.13
LOCUSID
5867
ALIAS
HRES-1,HRES-1/RAB4,HRES1,RAB4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5867
MIM: 179511
HGNC: 9781
Ensembl: ENSG00000168118

Variants:

dbSNP: 5867
ClinVar: 5867
TCGA: ENSG00000168118
COSMIC: RAB4A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168118ENST00000366690P20338
ENSG00000168118ENST00000366690A0A024R3U9
ENSG00000168118ENST00000618010A0A087WYT5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the plasma membraneREACTOMER-HSA-1660499
Signaling by METREACTOMER-HSA-6806834
MET receptor recyclingREACTOMER-HSA-8875656
TBC/RABGAPsREACTOMER-HSA-8854214
RAB geranylgeranylationREACTOMER-HSA-8873719

References

Pubmed IDYearTitleCitations
374230342023Receptor-mediated internalization promotes increased endosome size and number in a RAB4- and RAB5-dependent manner.0
374230342023Receptor-mediated internalization promotes increased endosome size and number in a RAB4- and RAB5-dependent manner.0
363078642022RAB4A GTPase regulates epithelial-to-mesenchymal transition by modulating RAC1 activation.0
363078642022RAB4A GTPase regulates epithelial-to-mesenchymal transition by modulating RAC1 activation.0
320198122020Complex Rab4-Mediated Regulation of Endosomal Size and EGFR Activation.14
329679692020Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling.9
320198122020Complex Rab4-Mediated Regulation of Endosomal Size and EGFR Activation.14
329679692020Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling.9
315756632019L-type prostaglandin D synthase regulates the trafficking of the PGD(2) DP1 receptor by interacting with the GTPase Rab4.3
315756632019L-type prostaglandin D synthase regulates the trafficking of the PGD(2) DP1 receptor by interacting with the GTPase Rab4.3
286047482017Isoprenylcysteine carboxylmethyltransferase function is essential for RAB4A-mediated integrin β3 recycling, cell migration and cancer metastasis.16
286047482017Isoprenylcysteine carboxylmethyltransferase function is essential for RAB4A-mediated integrin β3 recycling, cell migration and cancer metastasis.16
267169522016Laminar Shear Stress Promotes Vascular Endothelial Cell Autophagy Through Upregulation with Rab4.13
267169522016Laminar Shear Stress Promotes Vascular Endothelial Cell Autophagy Through Upregulation with Rab4.13
264302122015Rabaptin5 is recruited to endosomes by Rab4 and Rabex5 to regulate endosome maturation.20

Citation

Dessen P

RAB4A (RAB4A, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41999/case-report-explorer/gene-fusions/hgnc