UQCRH (ubiquinol-cytochrome c reductase hinge protein)

2003-05-01  

Identity

HGNC
UQCRH
LOCATION
1p33
LOCUSID
7388
ALIAS
QCR6,UQCR8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7388
MIM: 613844
HGNC: 12590
Ensembl: ENSG00000173660

Variants:

dbSNP: 7388
ClinVar: 7388
TCGA: ENSG00000173660
COSMIC: UQCRH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173660ENST00000311672P07919
ENSG00000173660ENST00000489056A0A087X2B9
ENSG00000173660ENST00000496387A0A087WTF2

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
Alzheimer's diseaseKEGGko05010
Huntington's diseaseKEGGko05016
Oxidative phosphorylationKEGGhsa00190
Alzheimer's diseaseKEGGhsa05010
Parkinson's diseaseKEGGhsa05012
Huntington's diseaseKEGGhsa05016
Cardiac muscle contractionKEGGhsa04260
Cardiac muscle contractionKEGGko04260
Metabolic pathwaysKEGGhsa01100
Cytochrome bc1 complexKEGGhsa_M00152
Cytochrome bc1 complexKEGGM00152
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Respiratory electron transportREACTOMER-HSA-611105

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381812342024Association of abnormal NDUFB2 and UQCRH expression with venous thromboembolism in patients with liver cirrhosis.0
381812342024Association of abnormal NDUFB2 and UQCRH expression with venous thromboembolism in patients with liver cirrhosis.0
341338432022Genome-wide analysis of DNA methylation identifies the apoptosis-related gene UQCRH as a tumor suppressor in renal cancer.9
341338432022Genome-wide analysis of DNA methylation identifies the apoptosis-related gene UQCRH as a tumor suppressor in renal cancer.9
347509912021Characterising a homozygous two-exon deletion in UQCRH: comparing human and mouse phenotypes.5
347509912021Characterising a homozygous two-exon deletion in UQCRH: comparing human and mouse phenotypes.5
329291202020UQCRH downregulation promotes Warburg effect in renal cell carcinoma cells.11
329291202020UQCRH downregulation promotes Warburg effect in renal cell carcinoma cells.11
283323142017The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma.25
283323142017The mitochondrial hinge protein, UQCRH, is a novel prognostic factor for hepatocellular carcinoma.25
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
128817162003UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines.10
128817162003UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines.10

Citation

Dessen P

UQCRH (ubiquinol-cytochrome c reductase hinge protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/420/css/lib/gene-explorer/