RAB5C (RAB5C, member RAS oncogene family)

2003-11-01  

Identity

HGNC
RAB5C
LOCATION
17q21.2
LOCUSID
5878
ALIAS
L1880,RAB5CL,RAB5L,RABL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5878
MIM: 604037
HGNC: 9785
Ensembl: ENSG00000108774

Variants:

dbSNP: 5878
ClinVar: 5878
TCGA: ENSG00000108774
COSMIC: RAB5C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108774ENST00000346213P51148
ENSG00000108774ENST00000346213A0A024R1U4
ENSG00000108774ENST00000393860P51148
ENSG00000108774ENST00000393860A0A024R1U4
ENSG00000108774ENST00000547517P51148
ENSG00000108774ENST00000550406F8VSF8
ENSG00000108774ENST00000550504F8VWU4
ENSG00000108774ENST00000551338K7ENY4
ENSG00000108774ENST00000552162F8VVK3

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Ras signaling pathwayKEGGhsa04014
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Neutrophil degranulationREACTOMER-HSA-6798695
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198
TBC/RABGAPsREACTOMER-HSA-8854214
RAB geranylgeranylationREACTOMER-HSA-8873719

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382422902024Rab5c promotes RSV and ADV replication by autophagy in respiratory epithelial cells.0
382422902024Rab5c promotes RSV and ADV replication by autophagy in respiratory epithelial cells.0
364807892023RAB5C, a new mRNA binding target of HuR, regulates breast cancer cell proliferation.1
366574262023Long Non-Coding RNA BCAR4 Promotes Oxaliplatin Resistance in Colorectal Cancer by Modulating miR-484-3p/RAB5C Expression.1
372131582023Effects of miR-145 targeting rab5c and regulating MAPK / ERK signaling pathway on proliferation and invasion of thyroid papillary carcinoma cells.0
375520662023Macrocephaly and developmental delay caused by missense variants in RAB5C.0
364807892023RAB5C, a new mRNA binding target of HuR, regulates breast cancer cell proliferation.1
366574262023Long Non-Coding RNA BCAR4 Promotes Oxaliplatin Resistance in Colorectal Cancer by Modulating miR-484-3p/RAB5C Expression.1
372131582023Effects of miR-145 targeting rab5c and regulating MAPK / ERK signaling pathway on proliferation and invasion of thyroid papillary carcinoma cells.0
375520662023Macrocephaly and developmental delay caused by missense variants in RAB5C.0
339835392021The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis.16
343671312021Novel Host Protein TBC1D16, a GTPase Activating Protein of Rab5C, Inhibits Prototype Foamy Virus Replication.8
339835392021The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis.16
343671312021Novel Host Protein TBC1D16, a GTPase Activating Protein of Rab5C, Inhibits Prototype Foamy Virus Replication.8
327888782020MiR-145 functions as a tumor suppressor in Papillary Thyroid Cancer by inhibiting RAB5C.9

Citation

Dessen P

RAB5C (RAB5C, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42003/img/css/gene-fusions-explorer/