RALGDS (ral guanine nucleotide dissociation stimulator)

2003-02-01  

Identity

HGNC
RALGDS
LOCATION
9q34.13
LOCUSID
5900
ALIAS
RGDS,RGF,RalGEF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5900
MIM: 601619
HGNC: 9842
Ensembl: ENSG00000160271

Variants:

dbSNP: 5900
ClinVar: 5900
TCGA: ENSG00000160271
COSMIC: RALGDS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160271ENST00000372047Q12967
ENSG00000160271ENST00000372050Q12967
ENSG00000160271ENST00000372062Q12967
ENSG00000160271ENST00000393157Q12967
ENSG00000160271ENST00000393160Q12967
ENSG00000160271ENST00000424572Q5T7U6
ENSG00000160271ENST00000460587A0A2R8YE90
ENSG00000160271ENST00000477660A0A2R8YEX4

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Colorectal cancerKEGGko05210
Pancreatic cancerKEGGko05212
Pathways in cancerKEGGhsa05200
Colorectal cancerKEGGhsa05210
Pancreatic cancerKEGGhsa05212
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Signalling to ERKsREACTOMER-HSA-187687
Signalling to RASREACTOMER-HSA-167044
p38MAPK eventsREACTOMER-HSA-171007
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
227384012012Role of electrostatics in differential binding of RalGDS to Rap mutations E30D and K31E investigated by vibrational spectroscopy of thiocyanate probes.4
227384012012Role of electrostatics in differential binding of RalGDS to Rap mutations E30D and K31E investigated by vibrational spectroscopy of thiocyanate probes.4
198011922009Ras classical effectors: new tales from in silico complexes.3
198011922009Ras classical effectors: new tales from in silico complexes.3
184177372008Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells.24
189482692008RalA functions as an indispensable signal mediator for the nutrient-sensing system.47
184177372008Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells.24
189482692008RalA functions as an indispensable signal mediator for the nutrient-sensing system.47
177093812007Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone.68
179921252007No evidence of RALGDS mutations in cutaneous melanoma.3
177093812007Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone.68
179921252007No evidence of RALGDS mutations in cutaneous melanoma.3
160072232005The merlin tumor suppressor interacts with Ral guanine nucleotide dissociation stimulator and inhibits its activity.9
160072232005The merlin tumor suppressor interacts with Ral guanine nucleotide dissociation stimulator and inhibits its activity.9
152083052004Activation of Ras-Ral pathway attenuates p53-independent DNA damage G2 checkpoint.8

Citation

Dessen P

RALGDS (ral guanine nucleotide dissociation stimulator)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42038/deep-insight-explorer/img/gene-explorer/