RFC3 (replication factor C subunit 3)

2003-02-01  

Identity

HGNC
LOCATION
13q13.2
LOCUSID
ALIAS
RFC38
FUSION GENES

Other Information

Locus ID:

NCBI: 5983
MIM: 600405
HGNC: 9971
Ensembl: ENSG00000133119

Variants:

dbSNP: 5983
ClinVar: 5983
TCGA: ENSG00000133119
COSMIC: RFC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133119ENST00000380071P40938
ENSG00000133119ENST00000380071A0A024RDQ8
ENSG00000133119ENST00000434425P40938
ENSG00000133119ENST00000616236A0A087X270

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
DNA replicationKEGGko03030
Nucleotide excision repairKEGGko03420
Mismatch repairKEGGko03430
DNA replicationKEGGhsa03030
Nucleotide excision repairKEGGhsa03420
Mismatch repairKEGGhsa03430
RF-C complexKEGGhsa_M00289
BRCA1-associated genome surveillance complex (BASC)KEGGhsa_M00295
RF-C complexKEGGM00289
BRCA1-associated genome surveillance complex (BASC)KEGGM00295
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Activation of ATR in response to replication stressREACTOMER-HSA-176187
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
DNA strand elongationREACTOMER-HSA-69190
Leading Strand SynthesisREACTOMER-HSA-69109
Polymerase switchingREACTOMER-HSA-69091
Lagging Strand SynthesisREACTOMER-HSA-69186
Chromosome MaintenanceREACTOMER-HSA-73886
Telomere MaintenanceREACTOMER-HSA-157579
Extension of TelomeresREACTOMER-HSA-180786
Telomere C-strand (Lagging Strand) SynthesisREACTOMER-HSA-174417
Polymerase switching on the C-strand of the telomereREACTOMER-HSA-174411
DNA ReplicationREACTOMER-HSA-69306
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
Resolution of AP sites via the multiple-nucleotide patch replacement pathwayREACTOMER-HSA-110373
PCNA-Dependent Long Patch Base Excision RepairREACTOMER-HSA-5651801
DNA Damage BypassREACTOMER-HSA-73893
Recognition of DNA damage by PCNA-containing replication complexREACTOMER-HSA-110314
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateREACTOMER-HSA-110313
Translesion synthesis by REV1REACTOMER-HSA-110312
Translesion Synthesis by POLHREACTOMER-HSA-110320
Translesion synthesis by POLKREACTOMER-HSA-5655862
Translesion synthesis by POLIREACTOMER-HSA-5656121
Termination of translesion DNA synthesisREACTOMER-HSA-5656169
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Presynaptic phase of homologous DNA pairing and strand exchangeREACTOMER-HSA-5693616
HDR through Single Strand Annealing (SSA)REACTOMER-HSA-5685938
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Dual Incision in GG-NERREACTOMER-HSA-5696400
Gap-filling DNA repair synthesis and ligation in GG-NERREACTOMER-HSA-5696397
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Dual incision in TC-NERREACTOMER-HSA-6782135
Gap-filling DNA repair synthesis and ligation in TC-NERREACTOMER-HSA-6782210
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383836982024Abnormal activation of RFC3, A YAP1/TEAD downstream target, promotes gastric cancer progression.1
383836982024Abnormal activation of RFC3, A YAP1/TEAD downstream target, promotes gastric cancer progression.1
378617472023RFC3 serves as a novel prognostic biomarker and target for head and neck squamous cell carcinoma.2
378617472023RFC3 serves as a novel prognostic biomarker and target for head and neck squamous cell carcinoma.2
349303592021IRF2 inhibits ZIKV replication by promoting FAM111A expression to enhance the host restriction effect of RFC3.3
349303592021IRF2 inhibits ZIKV replication by promoting FAM111A expression to enhance the host restriction effect of RFC3.3
316611242019RFC3 induces epithelial‑mesenchymal transition in lung adenocarcinoma cells through the Wnt/β‑catenin pathway and possesses prognostic value in lung adenocarcinoma.17
316611242019RFC3 induces epithelial‑mesenchymal transition in lung adenocarcinoma cells through the Wnt/β‑catenin pathway and possesses prognostic value in lung adenocarcinoma.17
255411532015Replication factor C3 is a CREB target gene that regulates cell cycle progression through the modulation of chromatin loading of PCNA.25
263971322015shRNA-mediated silencing of the RFC3 gene suppresses hepatocellular carcinoma cell proliferation.14
264646382015ShRNA-mediated silencing of the RFC3 gene suppress ovarian tumor cells proliferation.13
255411532015Replication factor C3 is a CREB target gene that regulates cell cycle progression through the modulation of chromatin loading of PCNA.25
263971322015shRNA-mediated silencing of the RFC3 gene suppresses hepatocellular carcinoma cell proliferation.14
264646382015ShRNA-mediated silencing of the RFC3 gene suppress ovarian tumor cells proliferation.13
250307352014Overexpression of RFC3 is correlated with ovarian tumor development and poor prognosis.13

Citation

Dessen P

RFC3 (replication factor C subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42089/favicon/meetings/