RGS1 (regulator of G protein signaling 1)

2003-02-01  

Identity

HGNC
RGS1
LOCATION
1q31.2
LOCUSID
5996
ALIAS
1R20,BL34,HEL-S-87,IER1,IR20
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5996
MIM: 600323
HGNC: 9991
Ensembl: ENSG00000090104

Variants:

dbSNP: 5996
ClinVar: 5996
TCGA: ENSG00000090104
COSMIC: RGS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090104ENST00000367459Q08116
ENSG00000090104ENST00000367459A0A024R945
ENSG00000090104ENST00000469578Q08116

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA172GNAI1GenePathwayassociated
PA173GNAI3GenePathwayassociated
PA175GNASGenePathwayassociated
PA24347GNAI2GenePathwayassociated

References

Pubmed IDYearTitleCitations
377352972024Regulator of G protein signaling-1 regulates immune infiltration and macrophage polarization in clear cell renal cell carcinoma.2
390150252024RGS1 and CREB5 are direct and common transcriptional targets of ZNF384-fusion proteins.1
377352972024Regulator of G protein signaling-1 regulates immune infiltration and macrophage polarization in clear cell renal cell carcinoma.2
390150252024RGS1 and CREB5 are direct and common transcriptional targets of ZNF384-fusion proteins.1
369387292023ScRNA-seq revealed targeting regulator of G protein signaling 1 to mediate regulatory T cells in Hepatocellular carcinoma.0
370731542023ATF3 Modulates the Proliferation, Migration, and Apoptosis of Synovial Fibroblasts after Arthroscopy by Promoting RGS1 Transcription.1
378509532023RGS1 Modulates Autophagic and Metabolic Programs and Is a Critical Mediator of Human Regulatory T Cell Function.1
382643432023Tumor-intrinsic RGS1 potentiates checkpoint blockade response via ATF3-IFNGR1 axis.1
369387292023ScRNA-seq revealed targeting regulator of G protein signaling 1 to mediate regulatory T cells in Hepatocellular carcinoma.0
370731542023ATF3 Modulates the Proliferation, Migration, and Apoptosis of Synovial Fibroblasts after Arthroscopy by Promoting RGS1 Transcription.1
378509532023RGS1 Modulates Autophagic and Metabolic Programs and Is a Critical Mediator of Human Regulatory T Cell Function.1
382643432023Tumor-intrinsic RGS1 potentiates checkpoint blockade response via ATF3-IFNGR1 axis.1
358797962022RGS1 and related genes as potential targets for immunotherapy in cervical cancer: computational biology and experimental validation.17
362731772022Identification of DNA methylation-regulated differentially expressed genes in RA by integrated analysis of DNA methylation and RNA-Seq data.3
358797962022RGS1 and related genes as potential targets for immunotherapy in cervical cancer: computational biology and experimental validation.17

Citation

Dessen P

RGS1 (regulator of G protein signaling 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42099/img/favicon/gene-fusions/?id=42099