PCGF2 (polycomb group ring finger 2)

2003-02-01  

Identity

HGNC
PCGF2
LOCATION
17q12
LOCUSID
7703
ALIAS
MEL-18,RNF110,TPFS,ZNF144
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7703
MIM: 600346
HGNC: 12929
Ensembl: ENSG00000277258

Variants:

dbSNP: 7703
ClinVar: 7703
TCGA: ENSG00000277258
COSMIC: PCGF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000277258ENST00000610747A0A087X0Y6
ENSG00000277258ENST00000611883P35227
ENSG00000277258ENST00000611883A0A024R1V6
ENSG00000277258ENST00000616129J3KT13
ENSG00000277258ENST00000616199P35227
ENSG00000277258ENST00000616199A0A024R1V6
ENSG00000277258ENST00000618506A0A087X259
ENSG00000277258ENST00000618941J3KT13
ENSG00000277258ENST00000620225P35227
ENSG00000277258ENST00000620225A0A024R1V6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Developmental BiologyREACTOMER-HSA-1266738
SUMOylation of RNA binding proteinsREACTOMER-HSA-4570464
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
354274252022SLCO4A1-AS1 triggers the malignant behaviours of melanoma cells via sponging miR-1306-5p to enhance PCGF2.2
354274252022SLCO4A1-AS1 triggers the malignant behaviours of melanoma cells via sponging miR-1306-5p to enhance PCGF2.2
336644522021AKT-mediated regulation of chromatin ubiquitylation and tumorigenesis through Mel18 phosphorylation.3
336644522021AKT-mediated regulation of chromatin ubiquitylation and tumorigenesis through Mel18 phosphorylation.3
270305462016PCGF2 negatively regulates arsenic trioxide-induced PML-RARA protein degradation via UBE2I inhibition in NB4 cells.6
275422292016Mel-18 negatively regulates stem cell-like properties through downregulation of miR-21 in gastric cancer.7
270305462016PCGF2 negatively regulates arsenic trioxide-induced PML-RARA protein degradation via UBE2I inhibition in NB4 cells.6
275422292016Mel-18 negatively regulates stem cell-like properties through downregulation of miR-21 in gastric cancer.7
258220212015MEL-18 loss mediates estrogen receptor-α downregulation and hormone independence.20
258220212015MEL-18 loss mediates estrogen receptor-α downregulation and hormone independence.20
234747522014Loss of the polycomb protein Mel-18 enhances the epithelial-mesenchymal transition by ZEB1 and ZEB2 expression through the downregulation of miR-205 in breast cancer.59
249649592014Expression and clinicopathological significance of Mel-18 mRNA in colorectal cancer.3
234747522014Loss of the polycomb protein Mel-18 enhances the epithelial-mesenchymal transition by ZEB1 and ZEB2 expression through the downregulation of miR-205 in breast cancer.59
249649592014Expression and clinicopathological significance of Mel-18 mRNA in colorectal cancer.3
229545902012Loss of Mel-18 enhances breast cancer stem cell activity and tumorigenicity through activating Notch signaling mediated by the Wnt/TCF pathway.24

Citation

Dessen P

PCGF2 (polycomb group ring finger 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42125/gene-fusions-explorer/deep-insight-explorer/js/lib/meetings/