RPL5 (ribosomal protein L5)

2003-06-01  

Identity

HGNC
LOCATION
1p22.1
LOCUSID
ALIAS
L5,MSTP030,PPP1R135,uL18
FUSION GENES

Other Information

Locus ID:

NCBI: 6125
MIM: 603634
HGNC: 10360
Ensembl: ENSG00000122406

Variants:

dbSNP: 6125
ClinVar: 6125
TCGA: ENSG00000122406
COSMIC: RPL5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122406ENST00000315741Q5T7N0
ENSG00000122406ENST00000370321P46777
ENSG00000122406ENST00000370321A2RUM7
ENSG00000122406ENST00000470843R4GNJ2
ENSG00000122406ENST00000645119A0A2R8Y4A2
ENSG00000122406ENST00000645300A0A2R8Y6J3

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
4000
4500
5000

Pathways

PathwaySourceExternal ID
RibosomeKEGGko03010
RibosomeKEGGhsa03010
Ribosome, eukaryotesKEGGhsa_M00177
Ribosome, eukaryotesKEGGM00177
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Eukaryotic Translation ElongationREACTOMER-HSA-156842
Peptide chain elongationREACTOMER-HSA-156902
Eukaryotic Translation TerminationREACTOMER-HSA-72764
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Influenza Viral RNA Transcription and ReplicationREACTOMER-HSA-168273
Viral mRNA TranslationREACTOMER-HSA-192823
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
Selenocysteine synthesisREACTOMER-HSA-2408557
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
352932752022Ribosomal protein L5 (RPL5)/ E2F transcription factor 1 (E2F1) signaling suppresses breast cancer progression via regulating endoplasmic reticulum stress and autophagy.7
353219192022Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly.4
358645882022DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.3
363844552022Ribosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway.8
352932752022Ribosomal protein L5 (RPL5)/ E2F transcription factor 1 (E2F1) signaling suppresses breast cancer progression via regulating endoplasmic reticulum stress and autophagy.7
353219192022Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly.4
358645882022DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.3
363844552022Ribosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway.8
340327492021The important role of MDM2, RPL5, and TP53 in mycophenolic acid-induced cleft lip and palate.0
344708342021Identification of RPL5 gene variants and the risk of hepatic vein thrombosis in Saudi patients.1
344834482021Genetic Variants of RPL5 and RPL9 Genes among Saudi Patients Diagnosed with Thrombosis.1
345876612021Investigation of the molecular causes underlying physical abnormalities in Diamond-Blackfan anemia patients with RPL5 haploinsufficiency.1
340327492021The important role of MDM2, RPL5, and TP53 in mycophenolic acid-induced cleft lip and palate.0
344708342021Identification of RPL5 gene variants and the risk of hepatic vein thrombosis in Saudi patients.1
344834482021Genetic Variants of RPL5 and RPL9 Genes among Saudi Patients Diagnosed with Thrombosis.1

Citation

Dessen P

RPL5 (ribosomal protein L5)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42157/js/gene-fusions/?id=42157