SAFB (scaffold attachment factor B)

2003-06-01  

Identity

HGNC
SAFB
LOCATION
19p13.3
LOCUSID
6294
ALIAS
HAP,HET,SAB-B1,SAF-B,SAF-B1,SAFB1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6294
MIM: 602895
HGNC: 10520
Ensembl: ENSG00000160633

Variants:

dbSNP: 6294
ClinVar: 6294
TCGA: ENSG00000160633
COSMIC: SAFB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160633ENST00000292123Q15424
ENSG00000160633ENST00000454510Q15424
ENSG00000160633ENST00000588852Q15424
ENSG00000160633ENST00000589006K7EII0
ENSG00000160633ENST00000589863K7ES42
ENSG00000160633ENST00000592224Q15424

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365771372023HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia.5
365771372023HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia.5
364273982022Short-term hypoxia triggers ROS and SAFB mediated nuclear matrix and mRNA splicing remodeling.4
364624982022SKA1 promotes tumor metastasis via SAFB-mediated transcription repression of DUSP6 in clear cell renal cell carcinoma.0
364273982022Short-term hypoxia triggers ROS and SAFB mediated nuclear matrix and mRNA splicing remodeling.4
364624982022SKA1 promotes tumor metastasis via SAFB-mediated transcription repression of DUSP6 in clear cell renal cell carcinoma.0
340671472021Inhibition of HSF1 and SAFB Granule Formation Enhances Apoptosis Induced by Heat Stress.7
341290972021Subcellular dynamics of estrogen-related receptors involved in transrepression through interactions with scaffold attachment factor B1.0
340671472021Inhibition of HSF1 and SAFB Granule Formation Enhances Apoptosis Induced by Heat Stress.7
341290972021Subcellular dynamics of estrogen-related receptors involved in transrepression through interactions with scaffold attachment factor B1.0
316779732020The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation.64
325802382020Abnormal scaffold attachment factor 1 expression and localization in spinocerebellar ataxias and Huntington's chorea.2
332575712020Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association.5
316779732020The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation.64
325802382020Abnormal scaffold attachment factor 1 expression and localization in spinocerebellar ataxias and Huntington's chorea.2

Citation

Dessen P

SAFB (scaffold attachment factor B)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42197/case-report-explorer/meetings/gene-explorer/