SEMA3C (semaphorin 3C)

2003-11-01  

Identity

HGNC
SEMA3C
LOCATION
7q21.11
LOCUSID
10512
ALIAS
SEMAE,SemE
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10512
MIM: 602645
HGNC: 10725
Ensembl: ENSG00000075223

Variants:

dbSNP: 10512
ClinVar: 10512
TCGA: ENSG00000075223
COSMIC: SEMA3C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000075223ENST00000265361Q99985
ENSG00000075223ENST00000411788F2Z2Y0
ENSG00000075223ENST00000419255Q99985
ENSG00000075223ENST00000427167F2Z2Y0
ENSG00000075223ENST00000458729F8WEP9

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD22664479
PA450085irinotecanChemicalClinicalAnnotationassociatedPD22664479

References

Pubmed IDYearTitleCitations
385281152024Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer.0
389560742024Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression.0
385281152024Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer.0
389560742024Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression.0
370550182023Semaphorin 3C exacerbates liver fibrosis.3
370809892023Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma.5
378006552023Semaphorin 3C promotes de novo steroidogenesis in prostate cancer cells.1
370550182023Semaphorin 3C exacerbates liver fibrosis.3
370809892023Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma.5
378006552023Semaphorin 3C promotes de novo steroidogenesis in prostate cancer cells.1
334203652021MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1-cMET signaling.36
335033182021SEMA3C induces androgen synthesis in prostatic stromal cells through paracrine signaling.0
335576562021Effect of semaphorin 3C gene variants in multifactorial Hirschsprung disease.2
335686742021LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C.13
340767802021Whole-genome sequencing identifies functional noncoding variation in SEMA3C that cosegregates with dyslexia in a multigenerational family.2

Citation

Dessen P

SEMA3C (semaphorin 3C)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42253/teaching-explorer/