SF1 (splicing factor 1)

2003-02-01  

Identity

HGNC
SF1
LOCATION
11q13.1
LOCUSID
7536
ALIAS
BBP,D11S636,MBBP,ZCCHC25,ZFM1,ZNF162
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7536
MIM: 601516
HGNC: 12950
Ensembl: ENSG00000168066

Variants:

dbSNP: 7536
ClinVar: 7536
TCGA: ENSG00000168066
COSMIC: SF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168066ENST00000227503Q15637
ENSG00000168066ENST00000227503A0A024R588
ENSG00000168066ENST00000334944Q15637
ENSG00000168066ENST00000334944A0A024R5D9
ENSG00000168066ENST00000377387Q15637
ENSG00000168066ENST00000377390Q15637
ENSG00000168066ENST00000377390A0A024R572
ENSG00000168066ENST00000377394Q15637
ENSG00000168066ENST00000377394A0A024R566
ENSG00000168066ENST00000413725H7C0N4
ENSG00000168066ENST00000413951F8WEG7
ENSG00000168066ENST00000432725C9J792
ENSG00000168066ENST00000433274Q15637
ENSG00000168066ENST00000443908H7BZT1
ENSG00000168066ENST00000448404F8WEV5
ENSG00000168066ENST00000486867H7C561
ENSG00000168066ENST00000626028F8WEV5

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
pituitary gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
361731642022Structural basis for the interaction between the first SURP domain of the SF3A1 subunit in U2 snRNP and the human splicing factor SF1.3
361731642022Structural basis for the interaction between the first SURP domain of the SF3A1 subunit in U2 snRNP and the human splicing factor SF1.3
319921352020Deoxynivalenol globally affects the selection of 3' splice sites in human cells by suppressing the splicing factors, U2AF1 and SF1.2
319921352020Deoxynivalenol globally affects the selection of 3' splice sites in human cells by suppressing the splicing factors, U2AF1 and SF1.2
280027342016SF1 Phosphorylation Enhances Specific Binding to U2AF(65) and Reduces Binding to 3'-Splice-Site RNA.11
280027342016SF1 Phosphorylation Enhances Specific Binding to U2AF(65) and Reduces Binding to 3'-Splice-Site RNA.11
256059642015Prp40 pre-mRNA processing factor 40 homolog B (PRPF40B) associates with SF1 and U2AF65 and modulates alternative pre-mRNA splicing in vivo.20
264208262015Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.25
256059642015Prp40 pre-mRNA processing factor 40 homolog B (PRPF40B) associates with SF1 and U2AF65 and modulates alternative pre-mRNA splicing in vivo.20
264208262015Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.25
250438502014Computational identification of post-translational modification-based nuclear import regulations by characterizing nuclear localization signal-import receptor interaction.1
251452642014Formation of nuclear bodies by the lncRNA Gomafu-associating proteins Celf3 and SF1.41
250438502014Computational identification of post-translational modification-based nuclear import regulations by characterizing nuclear localization signal-import receptor interaction.1
251452642014Formation of nuclear bodies by the lncRNA Gomafu-associating proteins Celf3 and SF1.41
232734252013Structure of phosphorylated SF1 bound to U2AF⁶⁵ in an essential splicing factor complex.21

Citation

Dessen P

SF1 (splicing factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42274/teaching-explorer/cancer-prone-explorer/gene-fusions-explorer/