Middle East Technical University, Department of Biological Sciences, Cankaya 06800, Ankara, Turkey; colgun@metu.edu.tr; mmuyan@metu.edu.tr
SNW1 is a spliceosomal component and transcriptional co-regulator that provides a modulatory coupling of transcription initiation and splicing. SNW1 appears to be an essential cancer cell survival factor by co-transcriptionally regulating mRNA splicing of proteins involved in cell cycle checkpoints. As a co-regulator, SNW1 is shown to attune the activity of a number of transcription factors, including nuclear hormone receptors as well as CBF1, Smad2\/3, and MyoD by modulating a transition step between the repressing and activating transcription complex assembly. SNW1 is also involved in the cell cycle progression through the involvement in cell cycle checkpoint-dependent changes in gene expressions during cellular proliferation and viral infections.
NCBI: 22938 MIM: 603055 HGNC: 16696 Ensembl: ENSG00000100603
dbSNP: 22938 ClinVar: 22938 TCGA: ENSG00000100603 COSMIC: SNW1
Cagla Ece Olgun ; Mesut Muyan
SNW1 (SNW domain containing 1)
Atlas Genet Cytogenet Oncol Haematol. 2017-08-01
Online version: http://atlasgeneticsoncology.org/gene/42348/favicon/apple-touch-icon.png