RARG (retinoic acid receptor gamma)

2003-05-01  

Identity

HGNC
RARG
LOCATION
12q13.13
LOCUSID
5916
ALIAS
NR1B3,RARC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5916
MIM: 180190
HGNC: 9866
Ensembl: ENSG00000172819

Variants:

dbSNP: 5916
ClinVar: 5916
TCGA: ENSG00000172819
COSMIC: RARG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172819ENST00000338561P13631
ENSG00000172819ENST00000338561F1D8P1
ENSG00000172819ENST00000394426P13631
ENSG00000172819ENST00000425354P13631
ENSG00000172819ENST00000425354A8K3H3
ENSG00000172819ENST00000543726P13631
ENSG00000172819ENST00000546717H3BMK1
ENSG00000172819ENST00000550362H3BMH6
ENSG00000172819ENST00000551158H3BMY6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Retinoic AcidREACTOMER-HSA-5362517
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280
Developmental BiologyREACTOMER-HSA-1266738
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA130620651anthracyclines and related substancesChemicalClinicalAnnotationassociatedPD
PA166128121cardiotoxicityDiseaseClinicalAnnotationassociatedPD
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD
PA449212daunorubicinChemicalGuidelineAnnotationassociated
PA449412doxorubicinChemicalGuidelineAnnotationassociated

References

Pubmed IDYearTitleCitations
378286592024The Role of RARG rs2229774, SLC28A3 rs7853758, and UGT1A6*4 rs17863783 Single-nucleotide Polymorphisms in the Doxorubicin-induced Cardiotoxicity in Solid Childhood Tumors.0
382458692024Histone lactylation inhibits RARγ expression in macrophages to promote colorectal tumorigenesis through activation of TRAF6-IL-6-STAT3 signaling.3
378286592024The Role of RARG rs2229774, SLC28A3 rs7853758, and UGT1A6*4 rs17863783 Single-nucleotide Polymorphisms in the Doxorubicin-induced Cardiotoxicity in Solid Childhood Tumors.0
382458692024Histone lactylation inhibits RARγ expression in macrophages to promote colorectal tumorigenesis through activation of TRAF6-IL-6-STAT3 signaling.3
361833622023Retinoic acid receptor gamma is required for proliferation of pancreatic cancer cells.3
378979472023RARγ promotes the invasion and metastasis of thyroid carcinoma by activating the JAK1-STAT3-CD24/MMPs axis.0
361833622023Retinoic acid receptor gamma is required for proliferation of pancreatic cancer cells.3
378979472023RARγ promotes the invasion and metastasis of thyroid carcinoma by activating the JAK1-STAT3-CD24/MMPs axis.0
344704632021Polymorphisms in Vitamin A-Related Genes and Their Functions in Autoimmune Thyroid Disease.1
344704632021Polymorphisms in Vitamin A-Related Genes and Their Functions in Autoimmune Thyroid Disease.1
325872612020Variation in RARG increases susceptibility to doxorubicin-induced cardiotoxicity in patient specific induced pluripotent stem cell-derived cardiomyocytes.23
332521952020Temporal activation of LRH-1 and RAR-γ in human pluripotent stem cells induces a functional naïve-like state.8
325872612020Variation in RARG increases susceptibility to doxorubicin-induced cardiotoxicity in patient specific induced pluripotent stem cell-derived cardiomyocytes.23
332521952020Temporal activation of LRH-1 and RAR-γ in human pluripotent stem cells induces a functional naïve-like state.8
301204112019The miR-96 and RARγ signaling axis governs androgen signaling and prostate cancer progression.28

Citation

Dessen P

RARG (retinoic acid receptor gamma)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42049/rarg-(retinoic-acid-receptor-gamma)