PDPN (podoplanin)

2003-05-01  

Identity

HGNC
PDPN
LOCATION
1p36.21
LOCUSID
10630
ALIAS
AGGRUS,GP36,GP40,Gp38,HT1A-1,OTS8,PA2.26,T1A,T1A-2,T1A2,TI1A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10630
MIM: 608863
HGNC: 29602
Ensembl: ENSG00000162493

Variants:

dbSNP: 10630
ClinVar: 10630
TCGA: ENSG00000162493
COSMIC: PDPN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162493ENST00000294489Q86YL7
ENSG00000162493ENST00000376057Q86YL7
ENSG00000162493ENST00000376061Q86YL7
ENSG00000162493ENST00000475043Q86YL7
ENSG00000162493ENST00000487038Q86YL7
ENSG00000162493ENST00000488631D6RH07
ENSG00000162493ENST00000506205H0Y8Q3
ENSG00000162493ENST00000509009E7ETC6
ENSG00000162493ENST00000510906H0YA72
ENSG00000162493ENST00000513143Q86YL7
ENSG00000162493ENST00000617617Q86YL7
ENSG00000162493ENST00000621990Q86YL7

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
GPVI-mediated activation cascadeREACTOMER-HSA-114604

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378911182024Pre-operative incisional biopsy of oral squamous cell carcinoma: high podoplanin expression is related to perineural invasion and may be a useful predictor of disease progression.0
384700962024Exosome-transmitted podoplanin promotes tumor-associated macrophage-mediated immune tolerance in glioblastoma.1
386196832024Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model by Reducing the Expression of Pdpn.1
378911182024Pre-operative incisional biopsy of oral squamous cell carcinoma: high podoplanin expression is related to perineural invasion and may be a useful predictor of disease progression.0
384700962024Exosome-transmitted podoplanin promotes tumor-associated macrophage-mediated immune tolerance in glioblastoma.1
386196832024Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model by Reducing the Expression of Pdpn.1
361563212023Podoplanin promotes the carcinogenicity of gastric cancer by activating ezrin and mediating the crosstalk between tumour cells and cancer-associated fibroblasts.2
370937082023Overexpression of Podoplanin Predicts Poor Prognosis in Patients With Glioma.0
372986792023Co-Expression of Podoplanin and CD44 in Proliferative Vitreoretinopathy Epiretinal Membranes.1
374935782023Podoplanin Drives Amoeboid Invasion in Canine and Human Mucosal Melanoma.0
376587272023Podoplanin-positive cells located in the basal layer of Bowen disease include tumor cells with cancer stem cell properties.0
383840592023Expression of Claudin-4 and D2-40 and their significance in prostatic adenocarcinoma.0
361563212023Podoplanin promotes the carcinogenicity of gastric cancer by activating ezrin and mediating the crosstalk between tumour cells and cancer-associated fibroblasts.2
370937082023Overexpression of Podoplanin Predicts Poor Prognosis in Patients With Glioma.0
372986792023Co-Expression of Podoplanin and CD44 in Proliferative Vitreoretinopathy Epiretinal Membranes.1

Citation

Dessen P

PDPN (podoplanin)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42455/meetings/cancer-prone-explorer/