TCF7L2 (transcription factor 7 like 2)

2003-02-01  

Identity

HGNC
TCF7L2
LOCATION
10q25.2
LOCUSID
6934
ALIAS
TCF-4,TCF4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6934
MIM: 602228
HGNC: 11641
Ensembl: ENSG00000148737

Variants:

dbSNP: 6934
ClinVar: 6934
TCGA: ENSG00000148737
COSMIC: TCF7L2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148737ENST00000277945Q5JRY5
ENSG00000148737ENST00000346198Q5VVR5
ENSG00000148737ENST00000349937Q5VVR8
ENSG00000148737ENST00000352065Q9NQB0
ENSG00000148737ENST00000355717Q9NQB0
ENSG00000148737ENST00000355995Q9NQB0
ENSG00000148737ENST00000369386Q5JRY3
ENSG00000148737ENST00000369389Q5JRY4
ENSG00000148737ENST00000369395Q5VVR7
ENSG00000148737ENST00000369397Q9NQB0
ENSG00000148737ENST00000369397Q6FHW4
ENSG00000148737ENST00000466338A0A1B0GUV5
ENSG00000148737ENST00000470254H0YEE5
ENSG00000148737ENST00000480888A0A1B0GU84
ENSG00000148737ENST00000534894A0A0A0MTL7
ENSG00000148737ENST00000536810C6ZRK5
ENSG00000148737ENST00000538897Q9NQB0
ENSG00000148737ENST00000542695C6ZRJ6
ENSG00000148737ENST00000543371E2GH26
ENSG00000148737ENST00000545257C6ZRJ7
ENSG00000148737ENST00000627217Q9NQB0
ENSG00000148737ENST00000629706A0A0D9SGH8
ENSG00000148737ENST00000637574A0A1B0GVE1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Adherens junctionKEGGko04520
MelanogenesisKEGGko04916
Colorectal cancerKEGGko05210
Endometrial cancerKEGGko05213
Prostate cancerKEGGko05215
Thyroid cancerKEGGko05216
Basal cell carcinomaKEGGko05217
Acute myeloid leukemiaKEGGko05221
Wnt signaling pathwayKEGGhsa04310
Adherens junctionKEGGhsa04520
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Colorectal cancerKEGGhsa05210
Endometrial cancerKEGGhsa05213
Prostate cancerKEGGhsa05215
Thyroid cancerKEGGhsa05216
Basal cell carcinomaKEGGhsa05217
Acute myeloid leukemiaKEGGhsa05221
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Incretin synthesis, secretion, and inactivationREACTOMER-HSA-400508
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)REACTOMER-HSA-381771
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by WNT in cancerREACTOMER-HSA-4791275
TCF7L2 mutants don't bind CTBPREACTOMER-HSA-5339700
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Degradation of beta-catenin by the destruction complexREACTOMER-HSA-195253
Repression of WNT target genesREACTOMER-HSA-4641265
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Binding of TCF/LEF:CTNNB1 to target gene promotersREACTOMER-HSA-4411364
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10390sulfonamides, urea derivativesChemicalClinicalAnnotationassociatedPD17519421, 21114608
PA164712689Dipeptidyl peptidase 4 (DPP-4) inhibitorsChemicalMultilinkAnnotationassociated27166975
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPD21857094, 23041303
PA443890Diabetes Mellitus, Type 2DiseaseClinicalAnnotation, Literature, MultilinkAnnotationassociatedPD17519421, 20054294, 24595071
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD
PA447247liver transplantationDiseaseClinicalAnnotationassociatedPD21857094, 23041303
PA449167cyclosporineChemicalClinicalAnnotationassociatedPD21857094, 23041303
PA449899hydrochlorothiazideChemicalClinicalAnnotationassociatedPD
PA451234repaglinideChemicalClinicalAnnotationassociatedPD20054294
PA451365sirolimusChemicalClinicalAnnotationassociatedPD21857094, 23041303
PA451578tacrolimusChemicalClinicalAnnotationassociatedPD21857094, 23041303

References

Pubmed IDYearTitleCitations
377984192024Astrocytic β-catenin signaling via TCF7L2 regulates synapse development and social behavior.3
380720132024Coronary artery disease patients with rs7904519 (TCF7L2) are at a persistent risk of type 2 diabetes.0
381668772024Correlation between TCF7L2 and CAPN10 gene polymorphisms and gestational diabetes mellitus in different geographical regions: a meta-analysis.2
383721012024MiR-27a-3p exacerbates cell migration and invasion in right-sided/left-sided colorectal cancer by targeting TGFBR2/TCF7L2.0
384921042024Association of Polymorphic Variants of TCF7L2 and PPARG Genes with Metabolic Markers in Patients with Early Disorders of Carbohydrate Metabolism.0
386128492024TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case-Control Study.0
377984192024Astrocytic β-catenin signaling via TCF7L2 regulates synapse development and social behavior.3
380720132024Coronary artery disease patients with rs7904519 (TCF7L2) are at a persistent risk of type 2 diabetes.0
381668772024Correlation between TCF7L2 and CAPN10 gene polymorphisms and gestational diabetes mellitus in different geographical regions: a meta-analysis.2
383721012024MiR-27a-3p exacerbates cell migration and invasion in right-sided/left-sided colorectal cancer by targeting TGFBR2/TCF7L2.0
384921042024Association of Polymorphic Variants of TCF7L2 and PPARG Genes with Metabolic Markers in Patients with Early Disorders of Carbohydrate Metabolism.0
386128492024TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case-Control Study.0
336416582023TCF7L2 (rs7903146) But Not CDKAL1 (rs7754840) Gene Polymorphisms Increase the Risk of New-Onset Diabetes After Kidney Transplant.1
358107382023Association between Transcription Factor 7-Like 2 C/T Polymorphism and Diabetic Retinopathy Risk: A Meta-Analysis.3
362823372023Milder loss of insulin-containing islets in individuals with type 1 diabetes and type 2 diabetes-associated TCF7L2 genetic variants.0

Citation

Dessen P

TCF7L2 (transcription factor 7 like 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42496/img/css/lib/teaching-explorer/