TIMP1 (TIMP metallopeptidase inhibitor 1)

2003-02-01  

Identity

HGNC
TIMP1
LOCATION
Xp11.3
LOCUSID
7076
ALIAS
CLGI,EPA,EPO,HCI,TIMP,TIMP-1

Other Information

Locus ID:

NCBI: 7076
MIM: 305370
HGNC: 11820
Ensembl: ENSG00000102265

Variants:

dbSNP: 7076
ClinVar: 7076
TCGA: ENSG00000102265
COSMIC: TIMP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102265ENST00000218388P01033
ENSG00000102265ENST00000218388Q6FGX5
ENSG00000102265ENST00000377017Q5H9A7
ENSG00000102265ENST00000441738Q5H9B4
ENSG00000102265ENST00000445623H0Y789
ENSG00000102265ENST00000456754Q5H9B5

Expression (GTEx)

0
500
1000
1500
2000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HIF-1 signaling pathwayKEGGhsa04066
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380324692024Integration of single-cell transcriptomics and epigenetic analysis reveals enhancer-controlled TIMP1 as a regulator of ferroptosis in colorectal cancer.0
382905912024TIMP1/CHI3L1 facilitates glioma progression and immunosuppression via NF-κB activation.2
383583772024The role of sinusoidal endothelial cells and TIMP1 in the regulation of fibrosis in a novel human liver 3D NASH model.1
384998422024GnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes diabetic retinopathy progression.0
387283742024HLA-B and TIMP1 as hub genes of the ventricular remodeling caused by hypertension.0
387778262024TIMP-1 is an activator of MHC-I expression in myeloid dendritic cells with implications for tumor immunogenicity.0
380324692024Integration of single-cell transcriptomics and epigenetic analysis reveals enhancer-controlled TIMP1 as a regulator of ferroptosis in colorectal cancer.0
382905912024TIMP1/CHI3L1 facilitates glioma progression and immunosuppression via NF-κB activation.2
383583772024The role of sinusoidal endothelial cells and TIMP1 in the regulation of fibrosis in a novel human liver 3D NASH model.1
384998422024GnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes diabetic retinopathy progression.0
387283742024HLA-B and TIMP1 as hub genes of the ventricular remodeling caused by hypertension.0
387778262024TIMP-1 is an activator of MHC-I expression in myeloid dendritic cells with implications for tumor immunogenicity.0
361631482023Cut loose TIMP-1: an emerging cytokine in inflammation.22
365412092023TIMP1 represses sorafenib-triggered ferroptosis in colorectal cancer cells by activating the PI3K/Akt signaling pathway.8
366299082023TIMP-1 is a novel ligand of Amyloid Precursor Protein and triggers a proinflammatory phenotype in human monocytes.8

Citation

Dessen P

TIMP1 (TIMP metallopeptidase inhibitor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42571/js/lib/teaching-explorer/