TIMP3 (TIMP metallopeptidase inhibitor 3)

2003-02-01  

Identity

HGNC
TIMP3
LOCATION
22q12.3
LOCUSID
7078
ALIAS
HSMRK222,K222,K222TA2,SFD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7078
MIM: 188826
HGNC: 11822
Ensembl: ENSG00000100234

Variants:

dbSNP: 7078
ClinVar: 7078
TCGA: ENSG00000100234
COSMIC: TIMP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100234ENST00000266085P35625

Expression (GTEx)

0
500
1000
1500
2000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA30086KDRGenePathwayassociated20124951

References

Pubmed IDYearTitleCitations
383454072024Abnormal stress promotes intervertebral disc degeneration through WTAP/YTHDF2-dependent TIMP3 m6A modification.0
383692142024TIMP3/Wnt axis regulates gliosis of Müller glia.0
386010182024Review: Mechanisms of TIMP-3 accumulation and pathogenesis in Sorsby fundus dystrophy.0
386125552024Disease-Causing TIMP3 Variants and Deep Phenotyping of Two Czech Families with Sorsby Fundus Dystrophy Associated with Novel p.(Tyr152Cys) Mutation.0
387982562024Demethylation of TIMP2 and TIMP3 Inhibits Cell Proliferation, Migration, and Invasion in Pituitary Adenomas.0
383454072024Abnormal stress promotes intervertebral disc degeneration through WTAP/YTHDF2-dependent TIMP3 m6A modification.0
383692142024TIMP3/Wnt axis regulates gliosis of Müller glia.0
386010182024Review: Mechanisms of TIMP-3 accumulation and pathogenesis in Sorsby fundus dystrophy.0
386125552024Disease-Causing TIMP3 Variants and Deep Phenotyping of Two Czech Families with Sorsby Fundus Dystrophy Associated with Novel p.(Tyr152Cys) Mutation.0
387982562024Demethylation of TIMP2 and TIMP3 Inhibits Cell Proliferation, Migration, and Invasion in Pituitary Adenomas.0
360938872023Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in periodontitis.1
363339762023Circulating levels of tissue inhibitor of metalloproteinase 3, a protein with inhibitory effects on angiogenesis, are increased in pre-eclampsia.2
374141992023Targeting of HBP1/TIMP3 axis as a novel strategy against breast cancer.2
378444232023Loss of TIMP3, but not TIMP4, exacerbates thoracic and abdominal aortic aneurysm.0
360938872023Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in periodontitis.1

Citation

Dessen P

TIMP3 (TIMP metallopeptidase inhibitor 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42573/css/lib/gene-explorer/favicon/teaching-explorer/