ANO1 (anoctamin 1)

2003-11-01  

Identity

HGNC
ANO1
LOCATION
11q13.3
LOCUSID
55107
ALIAS
DOG1,ORAOV2,TAOS2,TMEM16A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55107
MIM: 610108
HGNC: 21625
Ensembl: ENSG00000131620

Variants:

dbSNP: 55107
ClinVar: 55107
TCGA: ENSG00000131620
COSMIC: ANO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131620ENST00000316296Q5XXA6
ENSG00000131620ENST00000355303Q5XXA6
ENSG00000131620ENST00000530480H0YDD9
ENSG00000131620ENST00000530676Q5XXA6
ENSG00000131620ENST00000531300E9PS90
ENSG00000131620ENST00000531349E9PNA7
ENSG00000131620ENST00000531604E9PP68

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
357685542024Function and Regulation of the Calcium-Activated Chloride Channel Anoctamin 1 (TMEM16A).2
380844092024Anoctamin-1 is induced by TGF-β and contributes to lung myofibroblast differentiation.0
381550022024TMEM16A enhances the activity of the Cdc42-NWASP signaling pathway to promote invasion and metastasis in oral squamous cell carcinoma.0
381933012024The TMEM16A channel as a potential therapeutic target in vascular disease.0
383361042024Ano1 regulates embryo transport by modulating intracellular calcium levels in oviduct smooth muscle.0
383528642024High ANO1 expression is a prognostic factor and correlated with an immunosuppressive tumor microenvironment in pancreatic cancer.0
387731642024Promoter hypermethylation as a novel regulator of ANO1 expression and function in prostate cancer bone metastasis.0
390464092024[Expressions of zinc homeostasis proteins, GPR39 and ANO1 mRNA in the sperm of asthenozoospermia patients and their clinical significance].0
357685542024Function and Regulation of the Calcium-Activated Chloride Channel Anoctamin 1 (TMEM16A).2
380844092024Anoctamin-1 is induced by TGF-β and contributes to lung myofibroblast differentiation.0
381550022024TMEM16A enhances the activity of the Cdc42-NWASP signaling pathway to promote invasion and metastasis in oral squamous cell carcinoma.0
381933012024The TMEM16A channel as a potential therapeutic target in vascular disease.0
383361042024Ano1 regulates embryo transport by modulating intracellular calcium levels in oviduct smooth muscle.0
383528642024High ANO1 expression is a prognostic factor and correlated with an immunosuppressive tumor microenvironment in pancreatic cancer.0
387731642024Promoter hypermethylation as a novel regulator of ANO1 expression and function in prostate cancer bone metastasis.0

Citation

Dessen P

ANO1 (anoctamin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42588/deep-insight-explorer/js/lib/cancer-prone-explorer/