TNFAIP8 (TNF alpha induced protein 8)

2004-02-01  

Identity

HGNC
TNFAIP8
LOCATION
5q23.1
LOCUSID
25816
ALIAS
GG2-1,MDC-3.13,NDED,SCC-S2,SCCS2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25816
MIM: 612111
HGNC: 17260
Ensembl: ENSG00000145779

Variants:

dbSNP: 25816
ClinVar: 25816
TCGA: ENSG00000145779
COSMIC: TNFAIP8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145779ENST00000274456O95379
ENSG00000145779ENST00000388882E5RIJ3
ENSG00000145779ENST00000415806J3KQT8
ENSG00000145779ENST00000503646O95379
ENSG00000145779ENST00000504642D6RCM8
ENSG00000145779ENST00000504771O95379
ENSG00000145779ENST00000513374O95379

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378280752023Kidney tubular epithelial cells control interstitial fibroblast fate by releasing TNFAIP8-encapsulated exosomes.4
379489862023Synovial fluid exosome-derived miR-182-5p alleviates osteoarthritis by downregulating TNFAIP8 and promoting autophagy through LC3 signaling.1
378280752023Kidney tubular epithelial cells control interstitial fibroblast fate by releasing TNFAIP8-encapsulated exosomes.4
379489862023Synovial fluid exosome-derived miR-182-5p alleviates osteoarthritis by downregulating TNFAIP8 and promoting autophagy through LC3 signaling.1
332273922021TNFAIP8 drives metabolic reprogramming to promote prostate cancer cell proliferation.5
335948952021Proteomic Analysis of Plasma sEVs Reveals That TNFAIP8 Is a New Biomarker of Cell Proliferation in Diabetic Retinopathy.11
336823172021TNFAIP8 regulates gastric cancer growth via mTOR-Akt-ULK1 pathway and autophagy signals.3
340363742021Current research status of TNFAIP8 in tumours and other inflammatory conditions (Review).2
346082642021Decoupling tumor cell metastasis from growth by cellular pilot protein TNFAIP8.2
332273922021TNFAIP8 drives metabolic reprogramming to promote prostate cancer cell proliferation.5
335948952021Proteomic Analysis of Plasma sEVs Reveals That TNFAIP8 Is a New Biomarker of Cell Proliferation in Diabetic Retinopathy.11
336823172021TNFAIP8 regulates gastric cancer growth via mTOR-Akt-ULK1 pathway and autophagy signals.3
340363742021Current research status of TNFAIP8 in tumours and other inflammatory conditions (Review).2
346082642021Decoupling tumor cell metastasis from growth by cellular pilot protein TNFAIP8.2
321522682020TNFAIP8 regulates autophagy, cell steatosis, and promotes hepatocellular carcinoma cell proliferation.20

Citation

Dessen P

TNFAIP8 (TNF alpha induced protein 8)

Atlas Genet Cytogenet Oncol Haematol. 2004-02-01

Online version: http://atlasgeneticsoncology.org/gene/42604/gene-fusions-explorer/css/welcome