TNFRSF13B (TNF receptor superfamily member 13B)

2003-06-01  

Identity

HGNC
TNFRSF13B
LOCATION
17p11.2
LOCUSID
23495
ALIAS
CD267,CVID,CVID2,IGAD2,RYZN,TACI,TNFRSF14B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23495
MIM: 604907
HGNC: 18153
Ensembl: ENSG00000240505

Variants:

dbSNP: 23495
ClinVar: 23495
TCGA: ENSG00000240505
COSMIC: TNFRSF13B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000240505ENST00000261652O14836
ENSG00000240505ENST00000261652Q4ACX1
ENSG00000240505ENST00000579315J3QR67
ENSG00000240505ENST00000583789O14836
ENSG00000240505ENST00000584950E7ER05

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Primary immunodeficiencyKEGGko05340
Cytokine-cytokine receptor interactionKEGGhsa04060
Primary immunodeficiencyKEGGhsa05340
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363050392023TNFRSF13B/TACI Mutations in Patients with Chronic Rhinosinusitis with Nasal Polyps.0
372728402023Features of Isoforms of Human Soluble TACI.0
375346332023TNFRSF13B gene mutation in familial acute myeloid leukemia: A new piece in the complex scenario of hereditary predisposition?0
363050392023TNFRSF13B/TACI Mutations in Patients with Chronic Rhinosinusitis with Nasal Polyps.0
372728402023Features of Isoforms of Human Soluble TACI.0
375346332023TNFRSF13B gene mutation in familial acute myeloid leukemia: A new piece in the complex scenario of hereditary predisposition?0
349220032022Resolving the polygenic aetiology of a late onset combined immune deficiency caused by NFKB1 haploinsufficiency and modified by PIK3R1 and TNFRSF13B variants.2
350174852022A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers.24
356863702022TACI variants as underlying condition in autoimmune neutropenia: Description of four cases.1
349220032022Resolving the polygenic aetiology of a late onset combined immune deficiency caused by NFKB1 haploinsufficiency and modified by PIK3R1 and TNFRSF13B variants.2
350174852022A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers.24
356863702022TACI variants as underlying condition in autoimmune neutropenia: Description of four cases.1
335864702021TNFRSF13B c.226G>A (p.Gly76Ser) as a Novel Causative Mutation for Pulmonary Arterial Hypertension.8
342470952021TACI deficiency - a complex system out of balance.13
342838112021TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells.3

Citation

Dessen P

TNFRSF13B (TNF receptor superfamily member 13B)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42613/img/gene-fusions/favicon/manifest.json