TNFRSF13C (TNF receptor superfamily member 13C)

2003-06-01  

Identity

HGNC
TNFRSF13C
LOCATION
22q13.2
LOCUSID
115650
ALIAS
BAFF-R,BAFFR,BROMIX,CD268,CVID4,prolixin

Other Information

Locus ID:

NCBI: 115650
MIM: 606269
HGNC: 17755
Ensembl: ENSG00000159958

Variants:

dbSNP: 115650
ClinVar: 115650
TCGA: ENSG00000159958
COSMIC: TNFRSF13C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159958ENST00000291232Q96RJ3
ENSG00000159958ENST00000291232Q5H8V1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Primary immunodeficiencyKEGGko05340
Cytokine-cytokine receptor interactionKEGGhsa04060
Primary immunodeficiencyKEGGhsa05340
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayREACTOMER-HSA-5676594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
363086632023CVID-Associated B Cell Activating Factor Receptor Variants Change Receptor Oligomerization, Ligand Binding, and Signaling Responses.2
367948672023Features of BAFF and APRIL receptors on circulating B cells in antineutrophil cytoplasmic antibody-associated vasculitis.1
374604082023BAFFR expression in circulating T follicular helper (CD4(+)CXCR5(+)PD-1(+)) and T peripheral helper (CD4(+)CXCR5(-)PD-1(+)) cells in systemic lupus erythematosus.2
363086632023CVID-Associated B Cell Activating Factor Receptor Variants Change Receptor Oligomerization, Ligand Binding, and Signaling Responses.2
367948672023Features of BAFF and APRIL receptors on circulating B cells in antineutrophil cytoplasmic antibody-associated vasculitis.1
374604082023BAFFR expression in circulating T follicular helper (CD4(+)CXCR5(+)PD-1(+)) and T peripheral helper (CD4(+)CXCR5(-)PD-1(+)) cells in systemic lupus erythematosus.2
350174852022A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers.24
352509862022Circulating Memory B Cells in Early Multiple Sclerosis Exhibit Increased IgA(+) Cells, Globally Decreased BAFF-R Expression and an EBV-Related IgM(+) Cell Signature.5
354605402022B-cell activating factor (BAFF), BAFF promoter and BAFF receptor allelic variants in hepatitis C virus related Cryoglobulinemic Vasculitis and Non-Hodgkin's Lymphoma.3
355634922022Decreased BAFF Receptor Expression and Unaltered B Cell Receptor Signaling in Circulating B Cells from Primary Sjögren's Syndrome Patients at Diagnosis.2
357679612022BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors.4
350174852022A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers.24
352509862022Circulating Memory B Cells in Early Multiple Sclerosis Exhibit Increased IgA(+) Cells, Globally Decreased BAFF-R Expression and an EBV-Related IgM(+) Cell Signature.5
354605402022B-cell activating factor (BAFF), BAFF promoter and BAFF receptor allelic variants in hepatitis C virus related Cryoglobulinemic Vasculitis and Non-Hodgkin's Lymphoma.3
355634922022Decreased BAFF Receptor Expression and Unaltered B Cell Receptor Signaling in Circulating B Cells from Primary Sjögren's Syndrome Patients at Diagnosis.2

Citation

Dessen P

TNFRSF13C (TNF receptor superfamily member 13C)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42614/meetings/favicon/manifest.json