TNFSF11 (TNF superfamily member 11)

2003-06-01  

Identity

HGNC
TNFSF11
LOCATION
13q14.11
LOCUSID
8600
ALIAS
CD254,ODF,OPGL,OPTB2,RANKL,TNLG6B,TRANCE,hRANKL2,sOdf
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8600
MIM: 602642
HGNC: 11926
Ensembl: ENSG00000120659

Variants:

dbSNP: 8600
ClinVar: 8600
TCGA: ENSG00000120659
COSMIC: TNFSF11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120659ENST00000239849O14788
ENSG00000120659ENST00000358545O14788
ENSG00000120659ENST00000358545Q54A98
ENSG00000120659ENST00000398795O14788
ENSG00000120659ENST00000398795Q5T9Y4
ENSG00000120659ENST00000405262O14788
ENSG00000120659ENST00000405262Q54A98
ENSG00000120659ENST00000544862O14788
ENSG00000120659ENST00000544862Q54A98

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Prolactin signaling pathwayKEGGhsa04917
Prolactin signaling pathwayKEGGko04917
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayREACTOMER-HSA-5676594
TNFs bind their physiological receptorsREACTOMER-HSA-5669034
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD
PA448432anastrozoleChemicalClinicalAnnotationassociatedPD
PA450196letrozoleChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
383828052024RANK/RANKL axis promotes migration, invasion, and metastasis of osteosarcoma via activating NF-κB pathway.0
385834392024Osteoprotegerin and receptor activator of the nuclear factor kappa B ligand (RANKL) in healthy pubertal girls - relationships with physical growth and classical bone turnover markers.0
385947792024Overexpression of TNFSF11 reduces GPX4 levels and increases sensitivity to ferroptosis inducers in lung adenocarcinoma.0
386141292024Accumulation of γδT cells in the decidua is promoted by RANKL which upregulates ICAM-1 via NF-κB.0
383828052024RANK/RANKL axis promotes migration, invasion, and metastasis of osteosarcoma via activating NF-κB pathway.0
385834392024Osteoprotegerin and receptor activator of the nuclear factor kappa B ligand (RANKL) in healthy pubertal girls - relationships with physical growth and classical bone turnover markers.0
385947792024Overexpression of TNFSF11 reduces GPX4 levels and increases sensitivity to ferroptosis inducers in lung adenocarcinoma.0
386141292024Accumulation of γδT cells in the decidua is promoted by RANKL which upregulates ICAM-1 via NF-κB.0
357269002023RANKL interferes with osteoclastogenesis in PEG-fused U937 cells through LGR4.0
362511452023NCX1 disturbs calcium homeostasis and promotes RANKL-induced osteoclast differentiation by regulating JNK/c-Fos/NFATc1 signaling pathway in multiple myeloma.1
364732042023RANKL and RANK in Cancer Therapy.1
364820642023Exosomal lncRNA HOTAIR promotes osteoclast differentiation by targeting TGF-β/PTHrP/RANKL pathway.6
365138102023RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts.8
365351212023Assessment of RANK/RANK-L prevalence and clinical significance in NSCLC European Thoracic Oncology Platform Lungscape cohort and SPLENDOUR randomized clinical trial.0
366529882023Expression of RANKL in breast cancer tissue in patients with fibrous dysplasia/McCune-Albright syndrome.0

Citation

Dessen P

TNFSF11 (TNF superfamily member 11)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42633/css/lib/haematological-explorer/gene-explorer/