TOP2B (DNA topoisomerase II beta)

2003-06-01 Affiliation

Identity

HGNC

TOP2B

LOCATION

3p24.2

LOCUSID

7155

ALIAS

TOPIIB,top2beta

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7155
MIM: 126431
HGNC: 11990
Ensembl: ENSG00000077097

Variants:

dbSNP: 7155
ClinVar: 7155
TCGA: ENSG00000077097
COSMIC: TOP2B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000077097	ENST00000264331	Q02880
ENSG00000077097	ENST00000413971	H7BZ82
ENSG00000077097	ENST00000424225	E9PCY5
ENSG00000077097	ENST00000435706	Q02880

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
SUMOylation	REACTOME	R-HSA-2990846
SUMO E3 ligases SUMOylate target proteins	REACTOME	R-HSA-3108232
SUMOylation of DNA replication proteins	REACTOME	R-HSA-4615885
Platinum drug resistance	KEGG	ko01524
Platinum drug resistance	KEGG	hsa01524

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA449259	dexrazoxane	Chemical	Pathway	associated			21048526
PA449412	doxorubicin	Chemical	Pathway	associated			21048526

References

Pubmed ID	Year	Title	Citations
16794079	2006	A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.	320
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
11927602	2002	Dynamics of human DNA topoisomerases IIalpha and IIbeta in living cells.	69
27582050	2016	Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders.	57
19902255	2010	Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes.	53
19902255	2010	Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes.	53
20201926	2010	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	45
17526531	2007	C-terminal regions of topoisomerase IIalpha and IIbeta determine isoform-specific functioning of the enzymes in vivo.	43
14996935	2004	Functional compatibility between isoform alpha and beta of type II DNA topoisomerase.	40
24808172	2014	Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2).	37

Citation

Dessen P

TOP2B (DNA topoisomerase II beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42660/top2b