Molecular Oncology Laboratory. Facultad de Medicina. CRIB. UCLM. Albacete, Spain (MLV); Department of Molecular Biology of Neuronal Signals, Max-Planck Institute of Experimental Medicine, Gottingen, Germany (LAP)
Modulation TRPM8 channels are activated by stimulation of tyrosin-kinase and protein G-coupled receptors. The channel is also capable of activating Gq protein (Klasen et al., 2012). PI(4,5)P2 acts as a positive modulator of cold and menthol sensitivity by changing the voltage-sensitivity of the channel (Rohacs et al., 2005; Daniels et al., 2009; Yudin and Rohacs, 2012). Protein Kinase C is implicated in TRPM8 desensitization (Yudin and Rohacs, 2012). Phospolipase C (PLC)-coupled receptors mediate adaptation of TRPM8 to thermal stimuli (Daniels et al., 2009; Yudin and Rohacs, 2012). There are indications of modulation by PKC and PKA, which would underlie reduced responses to cold and menthol in neurons in the presence of bradykinin and prostaglandin E2 (Latorre et al., 2011; Yudin and Rohacs, 2012). TRPM8 also co-expresses with TrkA, the high affinity tyrosine kinase receptor for NGF (Latorre et al., 2011).
NCBI: 79054 MIM: 606678 HGNC: 17961 Ensembl: ENSG00000144481
dbSNP: 79054 ClinVar: 79054 TCGA: ENSG00000144481 COSMIC: TRPM8
María Llanos Valero ; Luis A Pardo
TRPM8 (transient receptor potential cation channel, subfamily M, member 8)
Atlas Genet Cytogenet Oncol Haematol. 2013-05-01
Online version: http://atlasgeneticsoncology.org/gene/42709/css/lib/dataTables.bootstrap.min.css