Identity
HGNC
LOCATION
3q27.3
LOCUSID
ALIAS
BDK,BK,HMWK,KNG
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3827
MIM: 612358
HGNC: 6383
Ensembl: ENSG00000113889
Variants:
dbSNP: 3827
ClinVar: 3827
TCGA: ENSG00000113889
COSMIC: KNG1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000113889 | ENST00000287611 | P01042 |
| ENSG00000113889 | ENST00000447445 | P01042 |
| ENSG00000113889 | ENST00000644859 | P01042 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA452637 | hormonal contraceptives for systemic use | Chemical | ClinicalAnnotation | associated | PD | 28750087 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37703419 | 2024 | Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons. | 4 |
| 37703419 | 2024 | Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons. | 4 |
| 36934370 | 2023 | High preoperative bradykinin level is a risk factor for severe postoperative hypoxaemia in acute aortic dissection surgery. | 3 |
| 37442062 | 2023 | An HBV susceptibility variant of KNG1 modulates the therapeutic effects of interferons α and λ1 in HBV infection by promoting MAVS lysosomal degradation. | 0 |
| 36934370 | 2023 | High preoperative bradykinin level is a risk factor for severe postoperative hypoxaemia in acute aortic dissection surgery. | 3 |
| 37442062 | 2023 | An HBV susceptibility variant of KNG1 modulates the therapeutic effects of interferons α and λ1 in HBV infection by promoting MAVS lysosomal degradation. | 0 |
| 34494203 | 2022 | gC1qR Antibody Can Modulate Endothelial Cell Permeability in Angioedema. | 3 |
| 34494203 | 2022 | gC1qR Antibody Can Modulate Endothelial Cell Permeability in Angioedema. | 3 |
| 33129885 | 2021 | Pathways for bradykinin formation and interrelationship with complement as a cause of edematous lung in COVID-19 patients. | 16 |
| 33827130 | 2021 | Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure. | 8 |
| 33129885 | 2021 | Pathways for bradykinin formation and interrelationship with complement as a cause of edematous lung in COVID-19 patients. | 16 |
| 33827130 | 2021 | Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure. | 8 |
| 31412146 | 2020 | Differential processing of high-molecular-weight kininogen during normal pregnancy. | 1 |
| 31933486 | 2020 | Bradykinin and oxidative stress in patients with hereditary angioedema due to C1 inhibitor deficiency. | 4 |
| 32114020 | 2020 | Bradykinin stimulates prostaglandin E(2) release in human skeletal muscular fibroblasts. | 6 |
Citation
Dessen P
KNG1 (kininogen 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46049/kng1-(kininogen-1)
