ASAP3 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 3)

2003-05-01  

Identity

HGNC
ASAP3
LOCATION
1p36.12
LOCUSID
55616
ALIAS
ACAP4,CENTB6,DDEFL1,UPLC1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55616
MIM: 616594
HGNC: 14987
Ensembl: ENSG00000088280

Variants:

dbSNP: 55616
ClinVar: 55616
TCGA: ENSG00000088280
COSMIC: ASAP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000088280ENST00000336689Q8TDY4
ENSG00000088280ENST00000336689A0A024RAB1
ENSG00000088280ENST00000437606Q8TDY4
ENSG00000088280ENST00000465372H0YEB0
ENSG00000088280ENST00000475814H0YER8
ENSG00000088280ENST00000484418H0YE36
ENSG00000088280ENST00000492982E9PS98
ENSG00000088280ENST00000495646Q8TDY4
ENSG00000088280ENST00000608765V9GY49
ENSG00000088280ENST00000618240A0A087X0Y5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
305369962019MicroRNA-143-3p inhibits colorectal cancer metastases by targeting ITGA6 and ASAP3.36
311822822019ACAP4 interacts with CrkII to promote the recycling of integrin β1.2
305369962019MicroRNA-143-3p inhibits colorectal cancer metastases by targeting ITGA6 and ASAP3.36
311822822019ACAP4 interacts with CrkII to promote the recycling of integrin β1.2
303952692018Acetylation of ACAP4 regulates CCL18-elicited breast cancer cell migration and invasion.17
303952692018Acetylation of ACAP4 regulates CCL18-elicited breast cancer cell migration and invasion.17
285021112017Upregulation of ASAP3 contributes to colorectal carcinogenesis and indicates poor survival outcome.6
285021112017Upregulation of ASAP3 contributes to colorectal carcinogenesis and indicates poor survival outcome.6
240784472014ASAP3 expression in non-small cell lung cancer: association with cancer development and patients' clinical outcome.11
242846542014Loss of ASAP3 destabilizes cytoskeletal protein ACTG1 to suppress cancer cell migration.17
240784472014ASAP3 expression in non-small cell lung cancer: association with cancer development and patients' clinical outcome.11
242846542014Loss of ASAP3 destabilizes cytoskeletal protein ACTG1 to suppress cancer cell migration.17
237762072013Phosphorylation of the Bin, Amphiphysin, and RSV161/167 (BAR) domain of ACAP4 regulates membrane tubulation.11
237762072013Phosphorylation of the Bin, Amphiphysin, and RSV161/167 (BAR) domain of ACAP4 regulates membrane tubulation.11
220278262011ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin β1 recycling in cell migration.12

Citation

Dessen P

ASAP3 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42769/css/favicon/welcome