USP4 (ubiquitin specific peptidase 4)

2003-02-01  

Identity

HGNC
USP4
LOCATION
3p21.31
LOCUSID
7375
ALIAS
UNP,Unph
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7375
MIM: 603486
HGNC: 12627
Ensembl: ENSG00000114316

Variants:

dbSNP: 7375
ClinVar: 7375
TCGA: ENSG00000114316
COSMIC: USP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114316ENST00000265560Q13107
ENSG00000114316ENST00000265560A0A024R2T0
ENSG00000114316ENST00000351842Q13107
ENSG00000114316ENST00000351842A0A024R2X6
ENSG00000114316ENST00000415188C9JNU9
ENSG00000114316ENST00000416417Q13107
ENSG00000114316ENST00000431357H7C189

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TNF signalingREACTOMER-HSA-75893
TNFR1-induced proapoptotic signalingREACTOMER-HSA-5357786
TNFR1-induced NFkappaB signaling pathwayREACTOMER-HSA-5357956
Regulation of TNFR1 signalingREACTOMER-HSA-5357905
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383106892024USP4 regulates TUT1 ubiquitination status in concert with SART3.0
385561052024Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer.0
383106892024USP4 regulates TUT1 ubiquitination status in concert with SART3.0
385561052024Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer.0
370398232023Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells.0
373087462023High USP4 mRNA is associated with an HPV-positive status in head and neck squamous cell carcinoma patients.0
379498742023USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1.2
381342272023FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis.2
370398232023Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells.0
373087462023High USP4 mRNA is associated with an HPV-positive status in head and neck squamous cell carcinoma patients.0
379498742023USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1.2
381342272023FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis.2
350643362022Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFRβ and affect PDGF-BB-induced STAT3 signalling.4
357747992022Transcriptome Analysis and Single-Cell Sequencing Analysis Constructed the Ubiquitination-Related Signature in Glioma and Identified USP4 as a Novel Biomarker.8
363368602022The Deubiquitinating Enzyme USP4 Functions as an Oncoprotein in Gastric Cancer and Mediates NF-κB Signaling by Regulating PRL-3 Expression.3

Citation

Dessen P

USP4 (ubiquitin specific peptidase 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42771/gene-explorer/js/lib/css/hgnc