WNT7B (Wnt family member 7B)

2003-02-01  

Identity

HGNC
WNT7B
LOCATION
22q13.31
LOCUSID
7477
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7477
MIM: 601967
HGNC: 12787
Ensembl: ENSG00000188064

Variants:

dbSNP: 7477
ClinVar: 7477
TCGA: ENSG00000188064
COSMIC: WNT7B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188064ENST00000339464P56706
ENSG00000188064ENST00000409496A8K0G1
ENSG00000188064ENST00000410058B8A597
ENSG00000188064ENST00000410089B8A595
ENSG00000188064ENST00000428540B8A598

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Wnt signaling pathwayKEGGko04310
MelanogenesisKEGGko04916
Basal cell carcinomaKEGGko05217
mTOR signaling pathwayKEGGhsa04150
Wnt signaling pathwayKEGGhsa04310
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Signaling by WntREACTOMER-HSA-195721
WNT ligand biogenesis and traffickingREACTOMER-HSA-3238698
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

References

Pubmed IDYearTitleCitations
387341882024LINC01605 promotes malignant phenotypes of cervical cancer via miR-149-3p/WNT7B axis.0
387341882024LINC01605 promotes malignant phenotypes of cervical cancer via miR-149-3p/WNT7B axis.0
357903502023Bi-allelic variants in WNT7B disrupt the development of multiple organs in humans.1
364727252023Inhibition of Wnt7b reduces the proliferation, invasion, and migration of colorectal cancer cells.0
365175902023EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.3
357903502023Bi-allelic variants in WNT7B disrupt the development of multiple organs in humans.1
364727252023Inhibition of Wnt7b reduces the proliferation, invasion, and migration of colorectal cancer cells.0
365175902023EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.3
345625992022WNT7B represses epithelial-mesenchymal transition and stem-like properties in bladder urothelial carcinoma.9
349992542022The miR-34a/WNT7B modulates the sensitivity of cholangiocarcinoma cells to p53-mediated photodynamic therapy toxicity.1
345625992022WNT7B represses epithelial-mesenchymal transition and stem-like properties in bladder urothelial carcinoma.9
349992542022The miR-34a/WNT7B modulates the sensitivity of cholangiocarcinoma cells to p53-mediated photodynamic therapy toxicity.1
334329282021Epigenetic regulation of Wnt7b expression by the cis-acting long noncoding RNA Lnc-Rewind in muscle stem cells.13
335267672021A WNT7B-m(6)A-TCF7L2 positive feedback loop promotes gastric cancer progression and metastasis.17
336079552021Activation of WNT7b autocrine eases metastasis of colorectal cancer via epithelial to mesenchymal transition and predicts poor prognosis.9

Citation

Dessen P

WNT7B (Wnt family member 7B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42829/css/lib/hgnc