WNT8B (Wnt family member 8B)

2003-02-01 Affiliation

Identity

HGNC

WNT8B

LOCATION

10q24.31

LOCUSID

7479

ALIAS

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7479
MIM: 601396
HGNC: 12789
Ensembl: ENSG00000075290

Variants:

dbSNP: 7479
ClinVar: 7479
TCGA: ENSG00000075290
COSMIC: WNT8B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000075290	ENST00000343737	Q93098
ENSG00000075290	ENST00000343737	A0A384NKY7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
mTOR signaling pathway	KEGG	ko04150
Wnt signaling pathway	KEGG	ko04310
Melanogenesis	KEGG	ko04916
Basal cell carcinoma	KEGG	ko05217
mTOR signaling pathway	KEGG	hsa04150
Wnt signaling pathway	KEGG	hsa04310
Melanogenesis	KEGG	hsa04916
Pathways in cancer	KEGG	hsa05200
Basal cell carcinoma	KEGG	hsa05217
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Hippo signaling pathway	KEGG	hsa04390
Hippo signaling pathway	KEGG	ko04390
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Signaling pathways regulating pluripotency of stem cells	KEGG	hsa04550
Signaling pathways regulating pluripotency of stem cells	KEGG	ko04550
Wnt signaling	KEGG	hsa_M00677
Wnt signaling	KEGG	M00677
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class B/2 (Secretin family receptors)	REACTOME	R-HSA-373080
Signaling by Wnt	REACTOME	R-HSA-195721
WNT ligand biogenesis and trafficking	REACTOME	R-HSA-3238698
TCF dependent signaling in response to WNT	REACTOME	R-HSA-201681
Disassembly of the destruction complex and recruitment of AXIN to the membrane	REACTOME	R-HSA-4641262
Breast cancer	KEGG	ko05224
Breast cancer	KEGG	hsa05224

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
33197287	2021	Wnt8B, transcriptionally regulated by ZNF191, promotes cell proliferation of hepatocellular carcinoma via Wnt signaling.	10
34287269	2021	WNT8B as an Independent Prognostic Marker for Nasopharyngeal Carcinoma.	3
33197287	2021	Wnt8B, transcriptionally regulated by ZNF191, promotes cell proliferation of hepatocellular carcinoma via Wnt signaling.	10
34287269	2021	WNT8B as an Independent Prognostic Marker for Nasopharyngeal Carcinoma.	3
20972907	2010	[Mutation and expression of WNT8b gene and SHH gene in Hirschsprung disease].	2
20972907	2010	[Mutation and expression of WNT8b gene and SHH gene in Hirschsprung disease].	2
20972907	2010	[Mutation and expression of WNT8b gene and SHH gene in Hirschsprung disease].	2
20972907	2010	[Mutation and expression of WNT8b gene and SHH gene in Hirschsprung disease].	2
17390031	2007	Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs.	4
17390031	2007	Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs.	4
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	83
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	83
11788899	2002	Up-regulation of WNT8B mRNA in human gastric cancer.	11
11956596	2002	Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells.	6
11788899	2002	Up-regulation of WNT8B mRNA in human gastric cancer.	11

Citation

Dessen P

WNT8B (Wnt family member 8B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42831/favicon/tumors-explorer/gene-fusions-explorer/meetings/