XBP1 (X-box binding protein 1)

2003-12-01  

Identity

HGNC
XBP1
LOCATION
22q12.1
LOCUSID
7494
ALIAS
TREB-5,TREB5,XBP-1,XBP2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7494
MIM: 194355
HGNC: 12801
Ensembl: ENSG00000100219

Variants:

dbSNP: 7494
ClinVar: 7494
TCGA: ENSG00000100219
COSMIC: XBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100219ENST00000216037P17861
ENSG00000100219ENST00000216037A0A024R1F0
ENSG00000100219ENST00000344347P17861
ENSG00000100219ENST00000403532B1AHH2
ENSG00000100219ENST00000405219B1AHH1
ENSG00000100219ENST00000611155P17861

Expression (GTEx)

0
100
200
300
400
500
600
700
800
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
ATF6 (ATF6-alpha) activates chaperonesREACTOMER-HSA-381033
ATF6 (ATF6-alpha) activates chaperone genesREACTOMER-HSA-381183
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713176Platinum compoundsChemicalClinicalAnnotationassociatedPD23510626
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD23510626

References

Pubmed IDYearTitleCitations
381460012024Innate IRE1α-XBP1 activation by viral single-stranded RNA and its influence on lung cytokine production during SARS-CoV-2 pneumonia.0
383221642024Expression and Clinical Significance of IRE1-XBP1s, p62, and Caspase-3 in Colorectal Cancer Patients.0
386489022024The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection.0
386886492024Correlation Between Low Cytoplasmic Expression of XBP1 and the Likelihood of Surviving Hepatocellular Carcinoma.0
389673612024X-Box binding protein 1 downregulates SIRT6 to promote injury in pancreatic ductal epithelial cells.0
381460012024Innate IRE1α-XBP1 activation by viral single-stranded RNA and its influence on lung cytokine production during SARS-CoV-2 pneumonia.0
383221642024Expression and Clinical Significance of IRE1-XBP1s, p62, and Caspase-3 in Colorectal Cancer Patients.0
386489022024The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection.0
386886492024Correlation Between Low Cytoplasmic Expression of XBP1 and the Likelihood of Surviving Hepatocellular Carcinoma.0
389673612024X-Box binding protein 1 downregulates SIRT6 to promote injury in pancreatic ductal epithelial cells.0
366398352023XBP1-elicited environment by chemotherapy potentiates repopulation of tongue cancer cells by enhancing miR-22/lncRNA/KAT6B-dependent NF-κB signalling.2
367683382023Enhanced IRE1α Phosphorylation/Oligomerization-Triggered XBP1 Splicing Contributes to Parkin-Mediated Prevention of SH-SY5Y Cell Death under Nitrosative Stress.1
368282602023XBP1s acts as a transcription factor of IRE1α and promotes proliferation of colon cancer cells.3
370549442023Single-cell RNA sequencing reveals XBP1-SLC38A2 axis as a metabolic regulator in cytotoxic T lymphocytes in multiple myeloma.3
372247542023Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy.9

Citation

Dessen P

XBP1 (X-box binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42842/css/js/hgnc