PRKCH (protein kinase C eta)

2004-06-01 Affiliation

Identity

HGNC

PRKCH

LOCATION

14q23.1

LOCUSID

5583

ALIAS

PKC-L,PKCL,PRKCL,nPKC-eta

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5583
MIM: 605437
HGNC: 9403
Ensembl: ENSG00000027075

Variants:

dbSNP: 5583
ClinVar: 5583
TCGA: ENSG00000027075
COSMIC: PRKCH

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000027075	ENST00000332981	P24723
ENSG00000027075	ENST00000553265	G3V4Q9
ENSG00000027075	ENST00000553726	G3V4H0
ENSG00000027075	ENST00000553830	G3V5Y6
ENSG00000027075	ENST00000553831	G3V304
ENSG00000027075	ENST00000555082	P24723
ENSG00000027075	ENST00000555185	G3V4L3
ENSG00000027075	ENST00000555542	G3V4G6
ENSG00000027075	ENST00000555906	G3V3E7
ENSG00000027075	ENST00000556164	G3V5F8
ENSG00000027075	ENST00000556778	G3V4X4
ENSG00000027075	ENST00000557294	G3V520
ENSG00000027075	ENST00000557473	G3V5U5
ENSG00000027075	ENST00000557585	G3V4Q6
ENSG00000027075	ENST00000640011	A0A1W2PPU0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Vascular smooth muscle contraction	KEGG	hsa04270
Vascular smooth muscle contraction	KEGG	ko04270
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Effects of PIP2 hydrolysis	REACTOME	R-HSA-114508
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (z) signalling events	REACTOME	R-HSA-418597
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA128394595	PLCH1	Gene	Pathway	associated
PA134875646	PLCZ1	Gene	Pathway	associated
PA134914471	PLCH2	Gene	Pathway	associated
PA33384	PLCB1	Gene	Pathway	associated
PA33385	PLCB2	Gene	Pathway	associated
PA33386	PLCB3	Gene	Pathway	associated
PA33387	PLCB4	Gene	Pathway	associated
PA33388	PLCD1	Gene	Pathway	associated
PA33389	PLCD3	Gene	Pathway	associated
PA33390	PLCD4	Gene	Pathway	associated
PA33391	PLCE1	Gene	Pathway	associated
PA33392	PLCG1	Gene	Pathway	associated	20124951
PA33393	PLCG2	Gene	Pathway	associated	20124951
PA33394	PLCL1	Gene	Pathway	associated
PA33395	PLCL2	Gene	Pathway	associated
PA34183	RAF1	Gene	Pathway	associated	20124951
PA39	ADRB2	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
31875586	2020	PRKCH polymorphism is associated with rheumatoid arthritis in a Chinese population.	0
31875586	2020	PRKCH polymorphism is associated with rheumatoid arthritis in a Chinese population.	0
29482336	2019	Advanced Oxidation Protein Products Aggravate Tubulointerstitial Fibrosis Through Protein Kinase C-Dependent Mitochondrial Injury in Early Diabetic Nephropathy.	19
30562553	2019	Differential effects of protein kinase C-eta on apoptosis versus senescence.	4
29482336	2019	Advanced Oxidation Protein Products Aggravate Tubulointerstitial Fibrosis Through Protein Kinase C-Dependent Mitochondrial Injury in Early Diabetic Nephropathy.	19
30562553	2019	Differential effects of protein kinase C-eta on apoptosis versus senescence.	4
28596089	2017	PRKCH regulates hematopoietic stem cell function and predicts poor prognosis in acute myeloid leukemia.	7
28640647	2017	Influence of PRKCH gene polymorphism on antihypertensive response to amlodipine and telmisartan.	1
28939105	2017	Protein kinase C-eta regulates Mcl-1 level via ERK1.	6
28596089	2017	PRKCH regulates hematopoietic stem cell function and predicts poor prognosis in acute myeloid leukemia.	7
28640647	2017	Influence of PRKCH gene polymorphism on antihypertensive response to amlodipine and telmisartan.	1
28939105	2017	Protein kinase C-eta regulates Mcl-1 level via ERK1.	6
25370935	2015	PRKCH 1425G/A Polymorphism Predicts Recurrence of Ischemic Stroke in a Chinese Population.	3
25900926	2015	Protein kinase Cη polymorphism and the susceptibility to ischemic stroke in the Taiwan population.	2
26404773	2015	Inhibition of TRPC6 by protein kinase C isoforms in cultured human podocytes.	5

Citation

Dessen P

PRKCH (protein kinase C eta)

Atlas Genet Cytogenet Oncol Haematol. 2004-06-01

Online version: http://atlasgeneticsoncology.org/gene/42912/favicon/css/gene-fusions/?id=42912