PRKCH (protein kinase C eta)

2004-06-01  

Identity

HGNC
PRKCH
LOCATION
14q23.1
LOCUSID
5583
ALIAS
PKC-L,PKCL,PRKCL,nPKC-eta
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5583
MIM: 605437
HGNC: 9403
Ensembl: ENSG00000027075

Variants:

dbSNP: 5583
ClinVar: 5583
TCGA: ENSG00000027075
COSMIC: PRKCH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000027075ENST00000332981P24723
ENSG00000027075ENST00000553265G3V4Q9
ENSG00000027075ENST00000553726G3V4H0
ENSG00000027075ENST00000553830G3V5Y6
ENSG00000027075ENST00000553831G3V304
ENSG00000027075ENST00000555082P24723
ENSG00000027075ENST00000555185G3V4L3
ENSG00000027075ENST00000555542G3V4G6
ENSG00000027075ENST00000555906G3V3E7
ENSG00000027075ENST00000556164G3V5F8
ENSG00000027075ENST00000556778G3V4X4
ENSG00000027075ENST00000557294G3V520
ENSG00000027075ENST00000557473G3V5U5
ENSG00000027075ENST00000557585G3V4Q6
ENSG00000027075ENST00000640011A0A1W2PPU0

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Effects of PIP2 hydrolysisREACTOMER-HSA-114508
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (z) signalling eventsREACTOMER-HSA-418597
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128394595PLCH1GenePathwayassociated
PA134875646PLCZ1GenePathwayassociated
PA134914471PLCH2GenePathwayassociated
PA33384PLCB1GenePathwayassociated
PA33385PLCB2GenePathwayassociated
PA33386PLCB3GenePathwayassociated
PA33387PLCB4GenePathwayassociated
PA33388PLCD1GenePathwayassociated
PA33389PLCD3GenePathwayassociated
PA33390PLCD4GenePathwayassociated
PA33391PLCE1GenePathwayassociated
PA33392PLCG1GenePathwayassociated20124951
PA33393PLCG2GenePathwayassociated20124951
PA33394PLCL1GenePathwayassociated
PA33395PLCL2GenePathwayassociated
PA34183RAF1GenePathwayassociated20124951
PA39ADRB2GenePathwayassociated

References

Pubmed IDYearTitleCitations
318755862020PRKCH polymorphism is associated with rheumatoid arthritis in a Chinese population.0
318755862020PRKCH polymorphism is associated with rheumatoid arthritis in a Chinese population.0
294823362019Advanced Oxidation Protein Products Aggravate Tubulointerstitial Fibrosis Through Protein Kinase C-Dependent Mitochondrial Injury in Early Diabetic Nephropathy.19
305625532019Differential effects of protein kinase C-eta on apoptosis versus senescence.4
294823362019Advanced Oxidation Protein Products Aggravate Tubulointerstitial Fibrosis Through Protein Kinase C-Dependent Mitochondrial Injury in Early Diabetic Nephropathy.19
305625532019Differential effects of protein kinase C-eta on apoptosis versus senescence.4
285960892017PRKCH regulates hematopoietic stem cell function and predicts poor prognosis in acute myeloid leukemia.7
286406472017Influence of PRKCH gene polymorphism on antihypertensive response to amlodipine and telmisartan.1
289391052017Protein kinase C-eta regulates Mcl-1 level via ERK1.6
285960892017PRKCH regulates hematopoietic stem cell function and predicts poor prognosis in acute myeloid leukemia.7
286406472017Influence of PRKCH gene polymorphism on antihypertensive response to amlodipine and telmisartan.1
289391052017Protein kinase C-eta regulates Mcl-1 level via ERK1.6
253709352015PRKCH 1425G/A Polymorphism Predicts Recurrence of Ischemic Stroke in a Chinese Population.3
259009262015Protein kinase Cη polymorphism and the susceptibility to ischemic stroke in the Taiwan population.2
264047732015Inhibition of TRPC6 by protein kinase C isoforms in cultured human podocytes.5

Citation

Dessen P

PRKCH (protein kinase C eta)

Atlas Genet Cytogenet Oncol Haematol. 2004-06-01

Online version: http://atlasgeneticsoncology.org/gene/42912/haematological-explorer/favicon/teaching-explorer/