MSRB2 (methionine sulfoxide reductase B2)

2005-02-01  

Identity

HGNC
MSRB2
LOCATION
10p12.2
LOCUSID
22921
ALIAS
CBS-1,CBS1,CGI-131,MSRB,PILB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22921
MIM: 613782
HGNC: 17061
Ensembl: ENSG00000148450

Variants:

dbSNP: 22921
ClinVar: 22921
TCGA: ENSG00000148450
COSMIC: MSRB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148450ENST00000376510Q9Y3D2
ENSG00000148450ENST00000472663H0YE51

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein repairREACTOMER-HSA-5676934

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
310785232019Mitochondrial methionine sulfoxide reductase B2 links oxidative stress to Alzheimer's disease-like pathology.10
312826142019Mitochondrial MsrB2 serves as a switch and transducer for mitophagy.28
310785232019Mitochondrial methionine sulfoxide reductase B2 links oxidative stress to Alzheimer's disease-like pathology.10
312826142019Mitochondrial MsrB2 serves as a switch and transducer for mitophagy.28
267184102016Identification of activators of methionine sulfoxide reductases A and B.10
267184102016Identification of activators of methionine sulfoxide reductases A and B.10
250787552014Identification of the mitochondrial MSRB2 as a binding partner of LG72.9
250787552014Identification of the mitochondrial MSRB2 as a binding partner of LG72.9
239887882013Proteome alteration in oxidative stress-sensitive methionine sulfoxide reductase-silenced HEK293 cells.7
239887882013Proteome alteration in oxidative stress-sensitive methionine sulfoxide reductase-silenced HEK293 cells.7
226346332012Glutaredoxin serves as a reductant for methionine sulfoxide reductases with or without resolving cysteine.12
226346332012Glutaredoxin serves as a reductant for methionine sulfoxide reductases with or without resolving cysteine.12
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
192375032009Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair.48

Citation

Dessen P

MSRB2 (methionine sulfoxide reductase B2)

Atlas Genet Cytogenet Oncol Haematol. 2005-02-01

Online version: http://atlasgeneticsoncology.org/gene/43001/gene-explorer/js/lib/hgnc