AICDA (activation induced cytidine deaminase)

2006-10-01  

Identity

HGNC
AICDA
LOCATION
12p13.31
LOCUSID
57379
ALIAS
AID,ARP2,CDA2,HEL-S-284,HIGM2

Other Information

Locus ID:

NCBI: 57379
MIM: 605257
HGNC: 13203
Ensembl: ENSG00000111732

Variants:

dbSNP: 57379
ClinVar: 57379
TCGA: ENSG00000111732
COSMIC: AICDA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111732ENST00000229335Q9GZX7
ENSG00000111732ENST00000229335Q546Y9
ENSG00000111732ENST00000537228Q9GZX7
ENSG00000111732ENST00000543081H0YFL3
ENSG00000111732ENST00000544516H0YFP1
ENSG00000111732ENST00000545512H0YGF6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Primary immunodeficiencyKEGGko05340
Primary immunodeficiencyKEGGhsa05340
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672

References

Pubmed IDYearTitleCitations
372488422023[Activation-induced cytidine deaminase (AID) involved in the regulation of B cell immune senescence].0
373006952023Activation-induced cytidine deaminase displays an alternative co-factor for modulating PIM1 expression in diffuse large B cell lymphoma cell lines.0
376008172023The off-target effects of AID in carcinogenesis.1
379499722023Activation-induced cytidine deaminase an antibody diversification enzyme interacts with chromatin modifier UBN1 in B-cells.0
372488422023[Activation-induced cytidine deaminase (AID) involved in the regulation of B cell immune senescence].0
373006952023Activation-induced cytidine deaminase displays an alternative co-factor for modulating PIM1 expression in diffuse large B cell lymphoma cell lines.0
376008172023The off-target effects of AID in carcinogenesis.1
379499722023Activation-induced cytidine deaminase an antibody diversification enzyme interacts with chromatin modifier UBN1 in B-cells.0
347274032022AID is a poor prognostic marker of high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements.0
349839262022USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID.5
355037492022Epstein-Barr virus and malaria upregulate AID and APOBEC3 enzymes, but only AID seems to play a major mutagenic role in Burkitt lymphoma.3
355245502022Human activation-induced deaminase lacks strong replicative strand bias or preference for cytosines in hairpin loops.4
347274032022AID is a poor prognostic marker of high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements.0
349839262022USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID.5
355037492022Epstein-Barr virus and malaria upregulate AID and APOBEC3 enzymes, but only AID seems to play a major mutagenic role in Burkitt lymphoma.3

Citation

Dessen P

AICDA (activation induced cytidine deaminase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43110/gene-explorer/css/cancer-prone-explorer/